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Dhrs7b Gene Detail
Summary
  • Symbol
    Dhrs7b
  • Name
    dehydrogenase/reductase (SDR family) member 7B
  • Synonyms
    MGC:6908
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384931
    NCBI Gene: 216820
  • Gene Overview
    MyGene.info: DHRS7B
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:60830631-60858423 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384931
protein coding gene Chr11:60830631-60860195 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018427
protein coding gene Chr11:60752319-60784340 (+)
A/J MGP_AJ_G0018396
protein coding gene Chr11:58513943-58544309 (+)
AKR/J MGP_AKRJ_G0018366
protein coding gene Chr11:60366230-60391741 (+)
BALB/cJ MGP_BALBcJ_G0018367
protein coding gene Chr11:58811508-58840506 (+)
C3H/HeJ MGP_C3HHeJ_G0018180
protein coding gene Chr11:60309791-60340454 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018819
protein coding gene Chr11:62676747-62708459 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016465
protein coding gene Chr11:55655780-55686705 (+)
CAST/EiJ MGP_CASTEiJ_G0017737
protein coding gene Chr11:60414590-60446726 (+)
CBA/J MGP_CBAJ_G0018154
protein coding gene Chr11:65398358-65426294 (+)
DBA/2J MGP_DBA2J_G0018263
protein coding gene Chr11:58100879-58128590 (+)
FVB/NJ MGP_FVBNJ_G0018254
protein coding gene Chr11:57764445-57799644 (+)
LP/J MGP_LPJ_G0018336
protein coding gene Chr11:61328549-61357610 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018278
protein coding gene Chr11:66463864-66490264 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018860
protein coding gene Chr11:60462239-60492917 (+)
PWK/PhJ MGP_PWKPhJ_G0017510
protein coding gene Chr11:58680418-58710914 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017300
protein coding gene Chr11:60273012-60301930 (+)
WSB/EiJ MGP_WSBEiJ_G0017789
protein coding gene Chr11:60083940-60112528 (+)



Homology
more
  • Human Ortholog
    DHRS7B, dehydrogenase/reductase 7B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DHRS7B, dehydrogenase/reductase 7B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI-93, SDR32C1
  • Links
    NCBI Gene ID: 25979
    neXtProt AC: NX_Q6IAN0
    UniProt: Q6IAN0

  • Chr Location
    17p11.2; chr17:21123369-21191972 (+)  GRCh38.p7

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap mutation die by weaning age and exhibit esophageal and gastric lesions. Thymic atrophy and muscle degeneration is also seen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 216820 NCBI Gene Model | MGI Sequence Detail 27793 C57BL/6J ±  kb
transcript NM_001172112 RefSeq | MGI Sequence Detail 1582 C57BL/6  
polypeptide Q99J47 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR036291 NAD(P)-binding domain superfamily
    IPR020904 Short-chain dehydrogenase/reductase, conserved site
    IPR002347 Short-chain dehydrogenase/reductase SDR
Molecular
Reagents
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  • All nucleic 31
    cDNA 31

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144655, MGI:2144658
References
more
  • Summaries
    All 48
    Diseases 2
    Gene Ontology 5
    Phenotypes 25
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:251809 Lodhi IJ, et al., PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression. Cell Rep. 2017 Sep 19;20(12):2766-2774

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory