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Tspan8
Gene Detail
Symbol

Name
ID
Tspan8
tetraspanin 8
MGI:2384918
Synonyms
E330007O21Rik, Tm4sf3
Feature Type
protein coding gene
Genetic Map
Chromosome 10
63.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:115817284-115849893 bp, + strand
From Ensembl annotation of GRCm38

  32610 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20968  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TSPAN8
Protein SuperFamily: tetraspanin
Gene Tree: Tspan8

Human
homologs
TSPAN8, tetraspanin 8
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7103
neXtProt AC: NX_P19075

Human Synonyms: CO-029, TM4SF3

Human Chr (Location): 12q14.1-q21.1; chr12:71125093-71157999 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF , CvDC )
Interactions
Tspan8 interacts with 87 markers (Mir7-1, Mir16-1, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process negative regulation of blood coagulation
Component extracellular exosome, integral component of membrane, ...
Function integrin binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(57)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tspan8    NEW 
Molecular
reagents
All nucleic(57) cDNA(57)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000034127 (Evidence)
Entrez Gene 216350 (Evidence)
UniGene 22270
DFCI TC1607632, TC1580347
DoTS DT.101714846, DT.101704757, DT.101400158, DT.101375933, DT.533466, DT.94373923
NIA Mouse Gene Index U012029
Consensus CDS Project CCDS24181.1
International Mouse Phenotyping Consortium Status Tspan8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034127 Ensembl Gene Model | MGI Sequence Detail 32610 C57BL/6J ±  kb
transcript ENSMUST00000080630 Ensembl | MGI Sequence Detail 1416 Not Applicable 
polypeptide ENSMUSP00000079463 Ensembl | MGI Sequence Detail 235 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(385 from dbSNP Build 137)    SNPs within 2kb including multiple locations(387)
Protein-related
information
ResourceIDDescription
InterPro IPR000301 Tetraspanin
InterPro IPR018503 Tetraspanin, conserved site
InterPro IPR008952 Tetraspanin, EC2 domain
InterPro IPR018499 Tetraspanin/Peripherin
Protein Ontology PR:000016754 tetraspanin-8
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:133317 Garcia-Espana A, et al., Appearance of new tetraspanin genes during vertebrate evolution. Genomics. 2008 Apr;91(4):326-34
All references(34)
Other
accession IDs
MGI:2143915, MGI:2445135

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory