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Slc5a8
Gene Detail
 Symbol
Name
ID
Slc5a8
solute carrier family 5 (iodide transporter), member 8
MGI:2384916
Synonyms MGC:19357, SMCT
Feature Type protein coding gene
Genetic Map
Chromosome 10
44.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:88885992-88929505 bp, + strand
From Ensembl annotation of GRCm38

  43514 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:64832  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc5a8

Human
homologs
Human Homolog SLC5A8, solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
NCBI Gene ID 160728
neXtProt AC  NX_Q8N695
Human Synonyms  AIT, SMCT, SMCT1
Human Chr (Location)  12q23.1; chr12:101156216-101210238 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased lactate concentrations in the saliva and urine.
 
Interactions
Slc5a8 interacts with 336 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process apoptotic process, ion transport, ...
Component extracellular vesicular exosome, integral component of membrane, ...
Function symporter activity, transporter activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (3)    Images (4)
Theiler Stages: 23
Assay TypeResults
RNA in situ 6
cDNA source data(38)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000020062 (Evidence)
Entrez Gene216225 (Evidence)
UniGene77381
DFCITC1581709
DoTSDT.101359460, DT.55168860
NIA Mouse Gene IndexU011866
Consensus CDS ProjectCCDS36026.1
International Mouse Knockout Project StatusSlc5a8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020062 Ensembl Gene Model | MGI Sequence Detail 43514 C57BL/6J ±  kb
transcript ENSMUST00000020255 Ensembl | MGI Sequence Detail 5321 Not Applicable 
polypeptide ENSMUSP00000020255 Ensembl | MGI Sequence Detail 611 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(335 from dbSNP Build 137)    SNPs within 2kb including multiple locations(377)
Protein-related
information
ResourceIDDescription
InterPro IPR001734 Sodium/solute symporter
InterPro IPR019900 Sodium/solute symporter, subgroup
Protein Ontology PR:000015174 sodium-coupled monocarboxylate transporter 1
References (Earliest) J:93994 Gopal E, et al., Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate. J Biol Chem. 2004 Oct 22;279(43):44522-32
(Latest) J:205014 Elangovan S, et al., Molecular mechanism of SLC5A8 inactivation in breast cancer. Mol Cell Biol. 2013 Oct;33(19):3920-35
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory