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Hkdc1 Gene Detail
Summary
  • Symbol
    Hkdc1
  • Name
    hexokinase domain containing 1
  • Synonyms
    MGC:28816
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384910
    NCBI Gene: 216019
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:62383137-62422464 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    214 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384910
protein coding gene Chr10:62383137-62422491 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017296
protein coding gene Chr10:61810246-61851458 (-)
A/J MGP_AJ_G0017274
protein coding gene Chr10:59919527-59958123 (-)
AKR/J MGP_AKRJ_G0017234
protein coding gene Chr10:61481266-61521458 (-)
BALB/cJ MGP_BALBcJ_G0017234
protein coding gene Chr10:59998634-60040145 (-)
C3H/HeJ MGP_C3HHeJ_G0017057
protein coding gene Chr10:61401855-61442897 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017692
protein coding gene Chr10:64027136-64068359 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015382
protein coding gene Chr10:56888762-56928220 (-)
CAST/EiJ MGP_CASTEiJ_G0016628
protein coding gene Chr10:61447773-61488797 (-)
CBA/J MGP_CBAJ_G0017029
protein coding gene Chr10:66427099-66468609 (-)
DBA/2J MGP_DBA2J_G0017134
protein coding gene Chr10:59192809-59232406 (-)
FVB/NJ MGP_FVBNJ_G0017128
protein coding gene Chr10:58455506-58497372 (-)
LP/J MGP_LPJ_G0017208
protein coding gene Chr10:62196571-62238509 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017156
protein coding gene Chr10:68657168-68699131 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017730
protein coding gene Chr10:61319486-61360865 (-)
PWK/PhJ MGP_PWKPhJ_G0016411
protein coding gene Chr10:59056209-59096329 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016193
protein coding gene Chr10:60688696-60732183 (-)
WSB/EiJ MGP_WSBEiJ_G0016692
protein coding gene Chr10:61254822-61296260 (-)



Homology
more
  • Human Ortholog
    HKDC1, hexokinase domain containing 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HKDC1, hexokinase domain containing 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 80201
    neXtProt AC: NX_Q2TB90
    UniProt: Q2TB90

  • Chr Location
    10q22.1; chr10:69220303-69267559 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality prior to genotyping. Mice heterozygous for a knock-out allele exhibit impaired glucose tolerance and female-specific increased in hepatic triglyceride levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 216019 NCBI Gene Model | MGI Sequence Detail 39328 C57BL/6J ±  kb
    transcript NM_145419 RefSeq | MGI Sequence Detail 3497 Not Specified  
    polypeptide Q91W97 UniProt | EBI | MGI Sequence Detail 915 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:240354 Ludvik AE, et al., HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use. Endocrinology. 2016 Sep;157(9):3452-61

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory