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Rnpep Gene Detail
Summary
  • Symbol
    Rnpep
  • Name
    arginyl aminopeptidase (aminopeptidase B)
  • Synonyms
    MGC:29229
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384902
    NCBI Gene: 215615
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:135190447-135211765 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 58.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    696 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384902
 protein coding gene Chr1:135190447-135211822 (-)
129S1/SvImJ ENSMUSG00200007852
 protein coding gene Chr1:132803002-132824213 (-)
A/J ENSMUSG00195043769
 protein coding gene Chr1:131877621-131898828 (-)
AKR/J ENSMUSG00220044493
 protein coding gene Chr1:131754825-131776066 (-)
BALB/cJ ENSMUSG00180031489
 protein coding gene Chr1:132418297-132439675 (-)
C3H/HeJ ENSMUSG00175040540
 protein coding gene Chr1:132121794-132142990 (-)
C57BL/6NJ ENSMUSG00215045361
 protein coding gene Chr1:132120113-132141485 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014635
 protein coding gene Chr1:126865484-126885823 (-)
CAST/EiJ ENSTCUG00005034681
 protein coding gene Chr1:131038752-131059990 (-)
CBA/J ENSMUSG00210025847
 protein coding gene Chr1:132052199-132073316 (-)
DBA/2J ENSMUSG00185027884
 protein coding gene Chr1:136426000-136447235 (-)
FVB/NJ ENSMUSG00205042879
 protein coding gene Chr1:131387882-131409001 (-)
JF1/MsJ ENSUMUG00000040216
 protein coding gene Chr1:135551908-135573278 (-)
LP/J ENSMUSG00230036313
 protein coding gene Chr1:135953020-135974387 (-)
NOD/ShiLtJ ENSMUSG00190039825
 protein coding gene Chr1:132066296-132087412 (-)
NZO/HlLtJ ENSMUSG00225019660
 protein coding gene Chr1:139716078-139738283 (-)
PWK/PhJ ENSLUMG00010023190
 protein coding gene Chr1:131176089-131197493 (-)
SPRET/EiJ ENSMSPG00010011438
 protein coding gene Chr1:133976231-133997344 (-)
WSB/EiJ ENSIUOG00005043697
 protein coding gene Chr1:131809562-131830708 (-)



Homology
more
  • Human Ortholog
    RNPEP, arginyl aminopeptidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNPEP, arginyl aminopeptidase
  • Synonyms
    AP-B, APB
  • Links
    NCBI Gene ID: 6051
    UniProt: Q9H4A4

  • Chr Location
    1q32.1; chr1:201982372-202006147 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    619
  • Tissues
    22
  • cDNA Data
    158
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 215615 NCBI Gene Model | MGI Sequence Detail 21319 C57BL/6J ±  kb
transcript NR_185276 RefSeq | MGI Sequence Detail 2275 C57BL/6  
polypeptide Q8VCT3 UniProt | EBI | MGI Sequence Detail 650 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014147 aminopeptidase B
    (term hierarchy)
  • EC
    3.4.11.6
  • InterPro Domains
    IPR034015 Aminopeptidase, leukotriene A4 hydrolase-like
    IPR045357 Aminopeptidase N-like , N-terminal domain
    IPR042097 Aminopeptidase N-like , N-terminal domain superfamliy
    IPR016024 Armadillo-type fold
    IPR049980 Leukotriene A4 hydrolase-like, catalytic domain
    IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
    IPR015211 Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal
    IPR038502 Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily
    IPR014782 Peptidase M1, membrane alanine aminopeptidase
    IPR027268 Peptidase M4/M1, CTD superfamily
  • GlyGen
    Q8VCT3 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 159
    cDNA 158
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory