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Rnpep
Gene Detail
 Symbol
Name
ID
Rnpep
arginyl aminopeptidase (aminopeptidase B)
MGI:2384902
Synonyms MGC:29229
Feature Type protein coding gene
Genetic Map
Chromosome 1
58.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:135262712-135284084 bp, - strand
From VEGA annotation of GRCm38

  21373 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10628  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: leukotriene-A4 hydrolase
Gene Tree: Rnpep

Human
homologs
Human Homolog RNPEP, arginyl aminopeptidase (aminopeptidase B)
NCBI Gene ID 6051
neXtProt AC  NX_Q9H4A4
Human Chr (Location)  1q32; chr1:201982638-202006147 (+)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process leukotriene biosynthetic process, negative regulation of blood pressure, ...
Component external side of plasma membrane, extracellular region, ...
Function aminopeptidase activity, cobalt ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (22)    Tissues (22)    Images (3)
Theiler Stages: 21, 28
Assay TypeResults
RNA in situ 20
RT-PCR 2
cDNA source data(157)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(158) cDNA(157) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021833 (Evidence)
Ensembl Gene ModelENSMUSG00000041926 (Evidence)
Entrez Gene215615 (Evidence)
UniGene291048
DFCITC1574105, TC1588358, TC1778739
DoTSDT.101325670, DT.535709, DT.94185330, DT.94185332
NIA Mouse Gene IndexU021794
EC3.4.11.6
Consensus CDS ProjectCCDS15317.1, CCDS48373.1
International Mouse Knockout Project StatusRnpep
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021833 VEGA Gene Model | MGI Sequence Detail 21373 C57BL/6J ±  kb
transcript OTTMUST00000051810 VEGA | MGI Sequence Detail 2288 Not Applicable 
polypeptide OTTMUSP00000024450 VEGA | MGI Sequence Detail 650 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(5) UniProt(3)
Polymorphisms SNPs within 2kb(428 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
InterPro IPR015571 Peptidase M1, aminopeptidase B
InterPro IPR015211 Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
InterPro IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
Protein Ontology PR:000014147 aminopeptidase B
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory