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Rnpep
Gene Detail
Symbol

Name
ID
Rnpep
arginyl aminopeptidase (aminopeptidase B)
MGI:2384902
Synonyms
MGC:29229
Feature Type
protein coding gene
Genetic Map
Chromosome 1
58.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:135262712-135284084 bp, - strand
From VEGA annotation of GRCm38

  21373 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10628  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RNPEP
Protein SuperFamily: leukotriene-A4 hydrolase
Gene Tree: Rnpep

Human
homologs
RNPEP, arginyl aminopeptidase (aminopeptidase B)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6051
neXtProt AC: NX_Q9H4A4

Human Chr (Location): 1q32; chr1:201982638-202006147 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Rnpep interacts with 39 markers (Mir20a, Mir22, Mir106b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (22)    Tissues (22)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
RT-PCR 2
cDNA source data(157)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rnpep ; ZFIN rnpep    NEW 
Molecular
reagents
All nucleic(158) cDNA(157) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000021833 (Evidence)
Ensembl Gene Model ENSMUSG00000041926 (Evidence)
Entrez Gene 215615 (Evidence)
UniGene 291048
DFCI TC1574105, TC1778739, TC1588358
DoTS DT.101325670, DT.94185332, DT.535709, DT.94185330
NIA Mouse Gene Index U021794
EC 3.4.11.6
Consensus CDS Project CCDS15317.1, CCDS48373.1
International Mouse Phenotyping Consortium Status Rnpep
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021833 VEGA Gene Model | MGI Sequence Detail 21373 C57BL/6J ±  kb
transcript OTTMUST00000051810 VEGA | MGI Sequence Detail 2288 Not Applicable 
polypeptide OTTMUSP00000024450 VEGA | MGI Sequence Detail 650 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(5) UniProt(3)
Polymorphisms
SNPs within 2kb(428 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
InterPro IPR015571 Peptidase M1, aminopeptidase B
InterPro IPR015211 Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
InterPro IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
Protein Ontology PR:000014147 aminopeptidase B
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory