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Chtf18
Gene Detail
 Symbol
Name
ID
Chtf18
CTF18, chromosome transmission fidelity factor 18
MGI:2384887
Synonyms 6030457M03Rik, CTF18
Feature Type protein coding gene
Genetic Map
Chromosome 17
12.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:25718926-25727419 bp, - strand
From VEGA annotation of GRCm38

  8494 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32532  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Chtf18

Human
homologs
Human Homolog CHTF18, CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
NCBI Gene ID 63922
neXtProt AC  NX_Q8WVB6
Human Synonyms  C16orf41, C321D2.2, C321D2.3, C321D2.4, CHL12, Ctf18, RUVBL
Human Chr (Location)  16p13.3; chr16:788622-798074 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Radiation induced(2) Targeted(5)
Genomic Mutations involving Chtf18 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit partial prenatal lethality, reduced body and testis weight, defective male meiosis, impaired spermatogenesis, oligozoospermia, and reduced male fertility.
 
Phenotype Images(4)
Interactions
Chtf18 interacts with 193 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell cycle, DNA replication, ...
Component cytoplasm, membrane, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (37)    Tissues (21)    Images (1)
Theiler Stages: 22, 28
Assay TypeResults
Immunohistochemistry 16
RNA in situ 1
Northern blot 10
Western blot 2
RT-PCR 8
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(5) Primer pair(5)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000035879 (Evidence)
Ensembl Gene ModelENSMUSG00000019214 (Evidence)
Entrez Gene214901 (Evidence)
Consensus CDS ProjectCCDS28523.1
International Mouse Knockout Project StatusChtf18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035879 VEGA Gene Model | MGI Sequence Detail 8494 C57BL/6J ±  kb
transcript OTTMUST00000092003 VEGA | MGI Sequence Detail 3214 Not Applicable 
polypeptide OTTMUSP00000050754 VEGA | MGI Sequence Detail 969 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR003959 ATPase, AAA-type, core
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000005485 chromosome transmission fidelity protein 18
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:194119 Berkowitz KM, et al., Disruption of CHTF18 causes defective meiotic recombination in male mice. PLoS Genet. 2012;8(11):e1002996
All references(26)
Other
accession IDs
MGI:2441708

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory