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Tmprss4 Gene Detail
Summary
  • Symbol
    Tmprss4
  • Name
    transmembrane protease, serine 4
  • Synonyms
    MGC:29209
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384877
    NCBI Gene: 214523
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:45084024-45115390 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1051 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384877
 protein coding gene Chr9:45084024-45115417 (-)
129S1/SvImJ ENSMUSG00200017927
 protein coding gene Chr9:42161758-42193168 (-)
A/J ENSMUSG00195023018
 protein coding gene Chr9:41929149-41960507 (-)
AKR/J ENSMUSG00220034206
 protein coding gene Chr9:42006712-42038053 (-)
BALB/cJ ENSMUSG00180027050
 protein coding gene Chr9:42040868-42072223 (-)
C3H/HeJ ENSMUSG00175015402
 protein coding gene Chr9:42052759-42084112 (-)
C57BL/6NJ ENSMUSG00215016314
 protein coding gene Chr9:42004370-42035745 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032140
 protein coding gene Chr9:42052450-42084066 (-)
CAST/EiJ ENSTCUG00005013333
 protein coding gene Chr9:41990099-42021506 (-)
CBA/J ENSMUSG00210015666
 protein coding gene Chr9:42090333-42121689 (-)
DBA/2J ENSMUSG00185010019
 protein coding gene Chr9:42167424-42198780 (-)
FVB/NJ ENSMUSG00205039656
 protein coding gene Chr9:42406694-42438048 (-)
JF1/MsJ ENSUMUG00000017126
 protein coding gene Chr9:42201572-42232989 (-)
LP/J ENSMUSG00230035834
 protein coding gene Chr9:42452179-42483591 (-)
NOD/ShiLtJ ENSMUSG00190020561
 protein coding gene Chr9:42246184-42277539 (-)
NZO/HlLtJ ENSMUSG00225043920
 protein coding gene Chr9:42420318-42451689 (-)
PWK/PhJ ENSLUMG00010020648
 protein coding gene Chr9:42159924-42191349 (-)
SPRET/EiJ ENSMSPG00010010701
 protein coding gene Chr9:42919710-42954743 (-)
WSB/EiJ ENSIUOG00005019868
 protein coding gene Chr9:41650091-41681450 (-)



Homology
more
  • Human Ortholog
    TMPRSS4, transmembrane serine protease 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMPRSS4, transmembrane serine protease 4
  • Synonyms
    CAP2, CAPH2, MT-SP2, TMPRSS3
  • Links
    NCBI Gene ID: 56649
    UniProt: Q9NRS4

  • Chr Location
    11q23.3; chr11:118077012-118125510 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Mice homozygous for a knock-out allele appear healthy and response normally to a sodium-deficient diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    27
  • cDNA Data
    35
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032091 Ensembl Gene Model | MGI Sequence Detail 31367 C57BL/6J ±  kb
transcript ENSMUST00000034599 Ensembl | MGI Sequence Detail 2284 Not Applicable  
polypeptide ENSMUSP00000034599 Ensembl | MGI Sequence Detail 435 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 35
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:105558 Kim TS, et al., Phenotypic analysis of mice lacking the Tmprss2-encoded protease. Mol Cell Biol. 2006 Feb;26(3):965-75
  • Latest
    J:299145 Harbig A, et al., Transcriptome profiling and protease inhibition experiments identify proteases that activate H3N2 influenza A and influenza B viruses in murine airways. J Biol Chem. 2020 Aug 14;295(33):11388-11407
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory