Cdk5rap2
Gene Detail

Symbol Name ID

Cdk5rap2 CDK5 regulatory subunit associated protein 2 MGI:2384875

Synonyms

2900018K03Rik, an, MGC:38528, mKIAA1633

Feature Type

protein coding gene

Genetic Map

Chromosome 4

35.92 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr4:70216856-70410443 bp, - strand From VEGA annotation of GRCm38   193588 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Cdk5rap2

Human homologs

Human Homolog		CDK5RAP2, CDK5 regulatory subunit associated protein 2
NCBI Gene ID		55755
neXtProt AC		NX_Q96SN8
Human Synonyms		C48, Cep215, MCPH3
Human Chr (Location)		9q33.2; chr9:123151147-123342437 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CDK5RAP2

Alleles and phenotypes

All alleles(22) : Targeted(1) Gene trapped(20) Radiation induced(1)
 

Homozygous mutant phenotype varies by strain background. Severely affected mutants exhibit small size, severe anemia, and neonatal death. Mildly affected mutants are viable with mild macrocytic anemia, reduced fertility and radiation senstitivity.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	brain development, centrosome organization, ...
Component	cell junction, centrosome, ...
Function	calmodulin binding, microtubule binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (30)    Tissues (30)    Images (9)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	30

cDNA source data(129)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(130) cDNA(130)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000000307 (Evidence)
Ensembl Gene Model	ENSMUSG00000039298 (Evidence)
Entrez Gene	214444 (Evidence)
UniGene	379344
DFCI	TC1597098, TC1599271, TC1698997
DoTS	DT.101291497, DT.103572862, DT.91566275, DT.97350862
NIA Mouse Gene Index	U069009
Consensus CDS Project	CCDS38779.1
International Mouse Knockout Project Status	Cdk5rap2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000307	VEGA Gene Model | MGI Sequence Detail	193588	C57BL/6J
transcript	OTTMUST00000000784	VEGA | MGI Sequence Detail	11847	Not Applicable
polypeptide	OTTMUSP00000000351	VEGA | MGI Sequence Detail	1822	Not Applicable

All sequences(52) RefSeq(2) UniProt(7)

Polymorphisms

SNPs within 2kb(1380 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1382)

Protein-related information

Resource	ID	Description
InterPro	IPR012943	Spindle associated
Protein Ontology	PR:000005262	CDK5 regulatory subunit-associated protein 2

References

(Earliest) J:208 Hertwig P, Neue Mutationen und Koppelungsgruppen bei der Hausmaus. Z Indukt Abstamm Vererbungsl. 1942;80:220-246
(Latest) J:187715 Xie L, et al., Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation. Dev Cell. 2012 Aug 14;23(2):280-91
All references(59)

Other accession IDs

MGD-MRK-1317, MGI:1920103, MGI:88021