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Cdk5rap2
Gene Detail
 Symbol
Name
ID
Cdk5rap2
CDK5 regulatory subunit associated protein 2
MGI:2384875
Synonyms 2900018K03Rik, an, MGC:38528, mKIAA1633
Feature Type protein coding gene
Genetic Map
Chromosome 4
35.92 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:70216856-70410443 bp, - strand
From VEGA annotation of GRCm38

  193588 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Cdk5rap2

Human
homologs
Human Homolog CDK5RAP2, CDK5 regulatory subunit associated protein 2
NCBI Gene ID 55755
neXtProt AC  NX_Q96SN8
Human Synonyms  C48, Cep215, MCPH3
Human Chr (Location)  9q33.2; chr9:120388869-120580170 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CDK5RAP2
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(20) Radiation induced(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant phenotype varies by strain background. Severely affected mutants exhibit small size, severe anemia, and neonatal death. Mildly affected mutants are viable with mild macrocytic anemia, reduced fertility and radiation senstitivity.
 
Interactions
Cdk5rap2 interacts with 524 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process brain development, centrosome organization, ...
Component cell, cell junction, ...
Function calmodulin binding, microtubule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (30)    Tissues (30)    Images (9)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 30
cDNA source data(126)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(127) cDNA(127)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000000307 (Evidence)
Ensembl Gene ModelENSMUSG00000039298 (Evidence)
Entrez Gene214444 (Evidence)
UniGene379344
DFCITC1597098, TC1599271, TC1698997
DoTSDT.101291497, DT.103572862, DT.91566275, DT.97350862
NIA Mouse Gene IndexU069009
Consensus CDS ProjectCCDS38779.1
International Mouse Knockout Project StatusCdk5rap2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000307 VEGA Gene Model | MGI Sequence Detail 193588 C57BL/6J ±  kb
transcript OTTMUST00000000784 VEGA | MGI Sequence Detail 11847 Not Applicable 
polypeptide OTTMUSP00000000351 VEGA | MGI Sequence Detail 1822 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(18) UniProt(7)
Polymorphisms SNPs within 2kb(1380 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1382)
Protein-related
information
ResourceIDDescription
InterPro IPR012943 Spindle associated
Protein Ontology PR:000005262 CDK5 regulatory subunit-associated protein 2
References (Earliest) J:208 Hertwig P, Neue Mutationen und Koppelungsgruppen bei der Hausmaus. Z Indukt Abstamm Vererbungsl. 1942;80:220-246
(Latest) J:198011 Eom T, et al., NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Elife. 2013;2:e00178
All references(60)
Other
accession IDs
MGD-MRK-1317, MGI:1920103, MGI:88021

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory