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Slc24a1 Gene Detail
Summary
  • Symbol
    Slc24a1
  • Name
    solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
  • Synonyms
    MGC:27617
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384871
    NCBI Gene: 214111
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:64922861-64951607 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 35.00 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384871
protein coding gene Chr9:64922861-64951607 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034945
protein coding gene Chr9:64616825-64645564 (-)
A/J MGP_AJ_G0034925
protein coding gene Chr9:62449472-62478225 (-)
AKR/J MGP_AKRJ_G0034855
protein coding gene Chr9:63912053-63940788 (-)
BALB/cJ MGP_BALBcJ_G0034918
protein coding gene Chr9:62172383-62201129 (-)
C3H/HeJ MGP_C3HHeJ_G0034628
protein coding gene Chr9:64438328-64467091 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035437
protein coding gene Chr9:66391543-66421319 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032348
protein coding gene Chr9:62089590-62118603 (-)
CAST/EiJ MGP_CASTEiJ_G0033949
protein coding gene Chr9:64612291-64640816 (-)
CBA/J MGP_CBAJ_G0034599
protein coding gene Chr9:68686509-68716956 (-)
DBA/2J MGP_DBA2J_G0034758
protein coding gene Chr9:62226224-62254981 (-)
FVB/NJ MGP_FVBNJ_G0034700
protein coding gene Chr9:61531601-61561844 (-)
LP/J MGP_LPJ_G0034841
protein coding gene Chr9:64897600-64926342 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034742
protein coding gene Chr9:69954068-69982915 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035459
protein coding gene Chr9:64024450-64053213 (-)
PWK/PhJ MGP_PWKPhJ_G0033653
protein coding gene Chr9:62398113-62426688 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033487
protein coding gene Chr9:64287209-64316132 (-)
WSB/EiJ MGP_WSBEiJ_G0034062
protein coding gene Chr9:63919075-63947818 (-)



Homology
more
  • Human Ortholog
    SLC24A1, solute carrier family 24 member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC24A1, solute carrier family 24 member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CSNB1D, HsT17412, NCKX, NCKX1, RODX
  • Links
    NCBI Gene ID: 9187
    neXtProt AC: NX_O60721
    UniProt: O60721

  • Chr Location
    15q22.31; chr15:65611405-65660995 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Slc24a1 mouse models; 1 with human SLC24A1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display slow progressive retinal degeneration and develop stationary night blindness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 214111 NCBI Gene Model | MGI Sequence Detail 28747 C57BL/6J ±  kb
    transcript NM_144813 RefSeq | MGI Sequence Detail 5257 C57BL/6  
    polypeptide NP_659062 RefSeq | MGI Sequence Detail 1130 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR004837 Sodium/calcium exchanger membrane region
      IPR004481 Sodium/potassium/calcium exchanger
      IPR004817 Sodium/potassium/calcium exchanger 1
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 27
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:226323 Vinberg F, et al., A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease. Hum Mol Genet. 2015 Oct 15;24(20):5915-29

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory