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Prdm9
Gene Detail
 Symbol
Name
ID
Prdm9
PR domain containing 9
MGI:2384854
Synonyms Dsbc1, G1-419-29, Meisetz, MGC:21428, Rcr1, repro7
Feature Type protein coding gene
Genetic Map
Chromosome 17
8.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr17:15545119-15564354 bp, - strand
From VEGA annotation of GRCm38

  19236 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:104139  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle

Gene Tree: Prdm9

Human
homologs
Human Homolog PRDM9, PR domain containing 9
NCBI Gene ID 56979
neXtProt AC  NX_Q9NQV7
Human Synonyms  MEISETZ, MSBP3, PFM6, PRMD9, ZNF899
Human Chr (Location)  5p14; chr5:23507615-23528597 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(2) Endonuclease-mediated(1) Gene trapped(2) QTL(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice display male and female infertility, meitotic arrest, azoospermia, oocyte depletion and reduced testis weight.
 
Phenotype Images(1)
Interactions
Prdm9 interacts with 127 markers (Mir15a, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process chromatin modification, histone H3-K4 methylation, ...
Component chromosome, intracellular, ...
Function histone-lysine N-methyltransferase activity, histone methyltransferase activity (H3-K4 specific), ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (2)   
Theiler Stages: 19, 21
Assay TypeResults
RT-PCR 2
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(3) cDNA(10) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000032999 (Evidence)
Ensembl Gene ModelENSMUSG00000051977 (Evidence)
Entrez Gene213389 (Evidence)
UniGene215162
DFCITC1602983, TC1606014
DoTSDT.101355498, DT.101705013
NIA Mouse Gene IndexU037451
EC2.1.1.43
PDB4C1Q
Consensus CDS ProjectCCDS49963.1
International Mouse Knockout Project StatusPrdm9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032999 VEGA Gene Model | MGI Sequence Detail 19236 C57BL/6J ±  kb
transcript OTTMUST00000082303 VEGA | MGI Sequence Detail 1447 Not Applicable 
polypeptide OTTMUSP00000044100 VEGA | MGI Sequence Detail 283 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(12) UniProt(5)
Polymorphisms SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001909 Krueppel-associated box
InterPro IPR003655 Krueppel-associated box-related
InterPro IPR001214 SET domain
InterPro IPR019041 SSXRD motif
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000013190 histone-lysine N-methyltransferase PRDM9
References (Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:194116 Flachs P, et al., Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility. PLoS Genet. 2012;8(11):e1003044
All references(45)
Other
accession IDs
MGI:3512775, MGI:3801504, MGI:3839351

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory