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Tnpo2 Gene Detail
Summary
  • Symbol
    Tnpo2
  • Name
    transportin 2 (importin 3, karyopherin beta 2b)
  • Synonyms
    1110034O24Rik, Kpnb2b, MGC:6380, TRN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384849
    NCBI Gene: 212999
  • Gene Overview
    MyGene.info: TNPO2
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85036915-85057583 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384849
 protein coding gene Chr8:85036870-85057585 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033889
 protein coding gene Chr8:85982738-86003088 (+)
A/J MGP_AJ_G0033872
 protein coding gene Chr8:82584496-82605184 (+)
AKR/J MGP_AKRJ_G0033798
 protein coding gene Chr8:85039801-85063406 (+)
BALB/cJ MGP_BALBcJ_G0033865
 protein coding gene Chr8:82721043-82741600 (+)
C3H/HeJ MGP_C3HHeJ_G0033575
 protein coding gene Chr8:85658949-85682077 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034385
 protein coding gene Chr8:89272469-89294042 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031326
 protein coding gene Chr8:76387219-76408402 (+)
CAST/EiJ MGP_CASTEiJ_G0032905
 protein coding gene Chr8:85090438-85112210 (+)
CBA/J MGP_CBAJ_G0033551
 protein coding gene Chr8:92293565-92326676 (+)
DBA/2J MGP_DBA2J_G0033704
 protein coding gene Chr8:82223689-82244908 (+)
FVB/NJ MGP_FVBNJ_G0033652
 protein coding gene Chr8:81182361-81203921 (+)
LP/J MGP_LPJ_G0033796
 protein coding gene Chr8:86085717-86107268 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033694
 protein coding gene Chr8:94863268-94887114 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034402
 protein coding gene Chr8:85028416-85052307 (+)
PWK/PhJ MGP_PWKPhJ_G0032608
 protein coding gene Chr8:81469956-81490855 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032445
 protein coding gene Chr8:83837512-83860334 (+)
WSB/EiJ MGP_WSBEiJ_G0033018
 protein coding gene Chr8:85454342-85476536 (+)



Homology
more
  • Human Ortholog
    TNPO2, transportin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TNPO2, transportin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IPO3, KPNB2B, TRN2
  • Links
    NCBI Gene ID: 30000
    neXtProt AC: NX_O14787
    UniProt: O14787

  • Chr Location
    19p13.13; chr19:12699194-12723996 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 8381
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TNPO2
  • Gene Tree
    Tnpo2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    15
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031691 Ensembl Gene Model | MGI Sequence Detail 20669 C57BL/6J ±  kb
transcript ENSMUST00000093360 Ensembl | MGI Sequence Detail 4863 Not Applicable  
polypeptide ENSMUSP00000091051 Ensembl | MGI Sequence Detail 897 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR001494 Importin-beta, N-terminal domain
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 5
Other
Accession IDs
less
MGI:1915911, MGI:2142422, MGI:2142565, MGI:2142636
References
more
  • Summaries
    All 66
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 37
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
  • Latest
    J:266142 Grosjean F, et al., Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice. PLoS One. 2018;13(9):e0204366
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/06/2018
MGI 6.13 		The Jackson Laboratory