Tnpo2 MGI Mouse Gene Detail - MGI:2384849 - transportin 2 (importin 3, karyopherin beta 2b)

Symbol

Tnpo2
Name

transportin 2 (importin 3, karyopherin beta 2b)
Synonyms

1110034O24Rik, Kpnb2b, MGC:6380, TRN2

Feature Type

protein coding gene
IDs

MGI:2384849
NCBI Gene: 212999
Gene Overview

MyGene.info: TNPO2
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:85036915-85057583 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 41.51 cM
Mapping Data

2 experiments

SNPs within 2kb

161 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384849	protein coding gene	Chr8:85036873-85057585 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033889	protein coding gene	Chr8:85982738-86003088 (+)
A/J	MGP_AJ_G0033872	protein coding gene	Chr8:82584496-82605184 (+)
AKR/J	MGP_AKRJ_G0033798	protein coding gene	Chr8:85039801-85063406 (+)
BALB/cJ	MGP_BALBcJ_G0033865	protein coding gene	Chr8:82721043-82741600 (+)
C3H/HeJ	MGP_C3HHeJ_G0033575	protein coding gene	Chr8:85658949-85682077 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034385	protein coding gene	Chr8:89272469-89294042 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031326	protein coding gene	Chr8:76387219-76408402 (+)
CAST/EiJ	MGP_CASTEiJ_G0032905	protein coding gene	Chr8:85090438-85112210 (+)
CBA/J	MGP_CBAJ_G0033551	protein coding gene	Chr8:92293565-92326676 (+)
DBA/2J	MGP_DBA2J_G0033704	protein coding gene	Chr8:82223689-82244908 (+)
FVB/NJ	MGP_FVBNJ_G0033652	protein coding gene	Chr8:81182361-81203921 (+)
LP/J	MGP_LPJ_G0033796	protein coding gene	Chr8:86085717-86107268 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033694	protein coding gene	Chr8:94863268-94887114 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034402	protein coding gene	Chr8:85028416-85052307 (+)
PWK/PhJ	MGP_PWKPhJ_G0032608	protein coding gene	Chr8:81469956-81490855 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032445	protein coding gene	Chr8:83837512-83860334 (+)
WSB/EiJ	MGP_WSBEiJ_G0033018	protein coding gene	Chr8:85454342-85476536 (+)

Human Ortholog

TNPO2, transportin 2

Vertebrate Orthologs

9

Human Ortholog

TNPO2, transportin 2
Orthology source: HomoloGene, HGNC
Synonyms

IPO3, KPNB2B, TRN2
Links

HGNC:19998

NCBI Gene ID: 30000

neXtProt AC: NX_O14787

UniProt: O14787
Chr Location

19p13.13; chr19:12699194-12723996 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8381
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: TNPO2
Gene Tree

Tnpo2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
40 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

49
Chemically induced (other)

1
Gene trapped

44
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Tnpo2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

15
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tnpo2

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Tnpo2 interacts with 234 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

84
RefSeq

28
UniProt

5
CCDS

CCDS22491.1, CCDS90431.1

Ensembl

ENSMUSG00000031691 (Evidence)
NCBI Gene

212999

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031691	Ensembl Gene Model \| MGI Sequence Detail	20669	C57BL/6J	± kb
transcript	ENSMUST00000093360	Ensembl \| MGI Sequence Detail	4863	Not Applicable
polypeptide	ENSMUSP00000091051	Ensembl \| MGI Sequence Detail	897	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016514 transportin-2

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR040122 Importin beta family

IPR001494 Importin-beta, N-terminal domain

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All nucleic 15

cDNA 15

Microarray probesets 5

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MGI:1915911, MGI:2142422, MGI:2142565, MGI:2142636

Summaries

All 69

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 40
Earliest

J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
Latest

J:282477 Baldelomar EJ, et al., In vivo measurements of kidney glomerular number and size in healthy and Os(/+) mice using MRI. Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F865-F873

TSS for Tnpo2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78513	Chr8:85036886-85036902 (+)	-21 bp
Tssr78514	Chr8:85036906-85036925 (+)	1 bp
Tssr78515	Chr8:85036926-85036937 (+)	17 bp
Tssr78516	Chr8:85037151-85037210 (+)	266 bp
Tssr78517	Chr8:85037214-85037227 (+)	306 bp
Tssr78518	Chr8:85057222-85057268 (+)	20,330 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/05/2021 MGI 6.16