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Tnpo2 Gene Detail
Summary
  • Symbol
    Tnpo2
  • Name
    transportin 2 (importin 3, karyopherin beta 2b)
  • Synonyms
    1110034O24Rik, Kpnb2b, MGC:6380, TRN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384849
    NCBI Gene: 212999
  • Gene Overview
    MyGene.info: TNPO2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85036915-85057583 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384849
protein coding gene Chr8:85036870-85057585 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033889
protein coding gene Chr8:85982738-86003088 (+)
A/J MGP_AJ_G0033872
protein coding gene Chr8:82584496-82605184 (+)
AKR/J MGP_AKRJ_G0033798
protein coding gene Chr8:85039801-85063406 (+)
BALB/cJ MGP_BALBcJ_G0033865
protein coding gene Chr8:82721043-82741600 (+)
C3H/HeJ MGP_C3HHeJ_G0033575
protein coding gene Chr8:85658949-85682077 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034385
protein coding gene Chr8:89272469-89294042 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031326
protein coding gene Chr8:76387219-76408402 (+)
CAST/EiJ MGP_CASTEiJ_G0032905
protein coding gene Chr8:85090438-85112210 (+)
CBA/J MGP_CBAJ_G0033551
protein coding gene Chr8:92293565-92326676 (+)
DBA/2J MGP_DBA2J_G0033704
protein coding gene Chr8:82223689-82244908 (+)
FVB/NJ MGP_FVBNJ_G0033652
protein coding gene Chr8:81182361-81203921 (+)
LP/J MGP_LPJ_G0033796
protein coding gene Chr8:86085717-86107268 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033694
protein coding gene Chr8:94863268-94887114 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034402
protein coding gene Chr8:85028416-85052307 (+)
PWK/PhJ MGP_PWKPhJ_G0032608
protein coding gene Chr8:81469956-81490855 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032445
protein coding gene Chr8:83837512-83860334 (+)
WSB/EiJ MGP_WSBEiJ_G0033018
protein coding gene Chr8:85454342-85476536 (+)



Homology
more
  • Human Ortholog
    TNPO2, transportin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TNPO2, transportin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IPO3, KPNB2B, TRN2
  • Links
    NCBI Gene ID: 30000
    neXtProt AC: NX_O14787
    UniProt: O14787

  • Chr Location
    19p13.13; chr19:12699194-12723996 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8381
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TNPO2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031691 Ensembl Gene Model | MGI Sequence Detail 20669 C57BL/6J ±  kb
transcript ENSMUST00000166592 Ensembl | MGI Sequence Detail 4884 Not Applicable  
polypeptide ENSMUSP00000133076 Ensembl | MGI Sequence Detail 897 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 5
Other
Accession IDs
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MGI:1915911, MGI:2142422, MGI:2142565, MGI:2142636
References
more
  • Summaries
    All 67
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 38
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
  • Latest
    J:266142 Grosjean F, et al., Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice. PLoS One. 2018;13(9):e0204366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory