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Nepro Gene Detail
Summary
  • Symbol
    Nepro
  • Name
    nucleolus and neural progenitor protein
  • Synonyms
    BC027231, MGC:27931
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384836
    NCBI Gene: 212547
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:44724301-44737284 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 29.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384836
protein coding gene Chr16:44724301-44738856 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022841
protein coding gene Chr16:43490697-43503678 (+)
A/J MGP_AJ_G0022806
protein coding gene Chr16:41542436-41555446 (+)
AKR/J MGP_AKRJ_G0022778
protein coding gene Chr16:42867222-42881579 (+)
BALB/cJ MGP_BALBcJ_G0022807
protein coding gene Chr16:41533323-41546303 (+)
C3H/HeJ MGP_C3HHeJ_G0022571
protein coding gene Chr16:43071239-43084221 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023254
protein coding gene Chr16:44479225-44492208 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020769
protein coding gene Chr16:41579419-41593113 (+)
CAST/EiJ MGP_CASTEiJ_G0022097
protein coding gene Chr16:43265541-43278850 (+)
CBA/J MGP_CBAJ_G0022542
protein coding gene Chr16:46368150-46381131 (+)
DBA/2J MGP_DBA2J_G0022674
protein coding gene Chr16:41274897-41287879 (+)
FVB/NJ MGP_FVBNJ_G0022649
protein coding gene Chr16:41232675-41245656 (+)
LP/J MGP_LPJ_G0022742
protein coding gene Chr16:43218237-43231974 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022668
protein coding gene Chr16:45746567-45759548 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023269
protein coding gene Chr16:42899874-42912856 (+)
PWK/PhJ MGP_PWKPhJ_G0021837
protein coding gene Chr16:41653490-41666822 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021668
protein coding gene Chr16:42806636-42821598 (+)
WSB/EiJ MGP_WSBEiJ_G0022141
protein coding gene Chr16:42994998-43007979 (+)



Homology
more
  • Human Ortholog
    NEPRO, nucleolus and neural progenitor protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEPRO, nucleolus and neural progenitor protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C3orf17, NET17
  • Links
    NCBI Gene ID: 25871
    neXtProt AC: NX_Q6NW34
    UniProt: Q6NW34

  • Chr Location
    3q13.2; chr3:113002444-113019733 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9127
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NEPRO
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality prior to implantation with a failure to form a blastocyst.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036208 Ensembl Gene Model | MGI Sequence Detail 12984 C57BL/6J ±  kb
transcript ENSMUST00000048788 Ensembl | MGI Sequence Detail 2866 Not Applicable  
polypeptide ENSMUSP00000038779 Ensembl | MGI Sequence Detail 564 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR027951 Domain of unknown function DUF4477
Molecular
Reagents
less
  • All nucleic 49
    cDNA 49

    Microarray probesets 4
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory