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Ap1ar
Gene Detail
Symbol

Name
ID
Ap1ar
adaptor-related protein complex 1 associated regulatory protein
MGI:2384822
Synonyms
Gadkin
Feature Type
protein coding gene
Genetic Map
Chromosome 3
56.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:127807007-127837523 bp, - strand
From VEGA annotation of GRCm38

  30517 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10236  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AP1AR
Gene Tree: Ap1ar

Human
homologs
AP1AR, adaptor-related protein complex 1 associated regulatory protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55435
neXtProt AC: NX_Q63HQ0

Human Synonyms: 2C18, C4orf16, gamma-BAR, GBAR, PRO0971

Human Chr (Location): 4q25; chr4:112231737-112272715 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Targeted(4)
Incidental mutations (data from CvDC )
Interactions
Ap1ar interacts with 204 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cellular protein localization, negative regulation of cell motility, ...
Component endosome, Golgi apparatus, ...
Function AP-1 adaptor complex binding, Arp2/3 complex binding, ...
External Resources: FuncBase
Expression
cDNA source data(64)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ap1ar    NEW 
Molecular
reagents
All nucleic(64) cDNA(64)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000052811 (Evidence)
Ensembl Gene Model ENSMUSG00000074238 (Evidence)
Entrez Gene 211556 (Evidence)
UniGene 403486
DFCI TC1584213, TC1603663, TC1626649, TC1644868, TC1774763
Consensus CDS Project CCDS38629.1
International Mouse Phenotyping Consortium Status Ap1ar
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052811 VEGA Gene Model | MGI Sequence Detail 30517 C57BL/6J ±  kb
transcript OTTMUST00000132178 VEGA | MGI Sequence Detail 2662 Not Applicable 
polypeptide OTTMUSP00000070510 VEGA | MGI Sequence Detail 298 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(18) UniProt(4)
Polymorphisms
SNPs within 2kb(404 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000031857 AP-1 complex-associated regulatory protein
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:185589 Maritzen T, et al., Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10382-7
All references(29)
Other
accession IDs
MGI:2139553, MGI:2140060

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory