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Ap1ar Gene Detail
Summary
  • Symbol
    Ap1ar
  • Name
    adaptor-related protein complex 1 associated regulatory protein
  • Synonyms
    Gadkin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384822
    NCBI Gene: 211556
  • Gene Overview
    MyGene.info: AP1AR
Location & Maps
more
  • Sequence Map
    Chr3:127807007-127837523 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30517 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 56.54 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    AP1AR, adaptor related protein complex 1 associated regulatory protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AP1AR, adaptor related protein complex 1 associated regulatory protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    2C18, C4orf16, gamma-BAR, GBAR, PRO0971
  • Links
    NCBI Gene ID: 55435
    neXtProt AC: NX_Q63HQ0

  • Chr Location
    4q25; chr4:112231737-112272715 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 10236
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: AP1AR
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Ap1ar
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052811 VEGA Gene Model | MGI Sequence Detail 30517 C57BL/6J ±  kb
transcript OTTMUST00000132178 VEGA | MGI Sequence Detail 2662 Not Applicable  
polypeptide OTTMUSP00000070510 VEGA | MGI Sequence Detail 298 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    393 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR031483 AP-1 complex-associated regulatory protein
Molecular
Reagents
less
  • All nucleic 64
    cDNA 64

    Microarray probesets 6
Other
Accession IDs
less
MGI:2139553, MGI:2140060
References
more
  • Summaries
    All 28
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:185589 Maritzen T, et al., Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10382-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory