Mtss1
Gene Detail

Symbol Name ID

Mtss1 metastasis suppressor 1 MGI:2384818

Synonyms

2310003N14Rik, D130001D01Rik, MGC:37896, MIM, mKIAA0429

Feature Type

protein coding gene

Genetic Map

Chromosome 15

25.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:58941244-59082026 bp, - strand From Ensembl annotation of GRCm38   140783 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8841  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Mtss1

Human homologs

Human Homolog		MTSS1, metastasis suppressor 1
NCBI Gene ID		9788
neXtProt AC		NX_O43312
Human Synonyms		MIM, MIMA, MIMB
Human Chr (Location)		8p22; chr8:125563025-125740730 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(186) : Targeted(5) Gene trapped(181)
 

Mice homozygous for a gene trap allele exhibit polycystic kidney in 50% of mice by 5 months of age. Mouse embryonic fibroblasts from mice homozygous for a different gene trap allele exhibit altered cell morphology and physiology.

 
Human Diseases Modeled Using Mouse Mtss1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	actin filament organization, actin filament polymerization, ...
Component	actin cytoskeleton, cytoplasm, ...
Function	actin binding, actin monomer binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (42)    Tissues (41)    Images (8)
Theiler Stages: 10, 17, 18, 19, 20, 23, 25, 26, 28

Assay Type	Results
RNA in situ	30
Northern blot	12

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(12) Other(1)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000022353 (Evidence)
Entrez Gene	211401 (Evidence)
DFCI	TC1580628, TC1598387, TC1600849, TC1600998, TC1605119, TC1611397, TC1639969
DoTS	DT.101382308, DT.101708872, DT.101741330, DT.110814576, DT.534378, DT.60102612, DT.94206095, DT.94406247, DT.97339976
NIA Mouse Gene Index	U084230, U328720
PDB	2D1L
Consensus CDS Project	CCDS27496.1
International Mouse Knockout Project Status	Mtss1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022353	Ensembl Gene Model | MGI Sequence Detail	140783	C57BL/6J
transcript	ENSMUST00000080371	Ensembl | MGI Sequence Detail	4965	Not Applicable
polypeptide	ENSMUSP00000079239	Ensembl | MGI Sequence Detail	759	Not Applicable

All sequences(52) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(830 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013606	IRSp53/MIM homology domain (IMD)
InterPro	IPR003124	WH2 domain
Protein Ontology	PR:000010751	metastasis suppressor protein 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(48)

Other accession IDs

MGI:1917337, MGI:2442868