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Mtss1
Gene Detail
Symbol

Name
ID
Mtss1
metastasis suppressor 1
MGI:2384818
Synonyms
2310003N14Rik, D130001D01Rik, MGC:37896, MIM, mKIAA0429
Feature Type
protein coding gene
Genetic Map
Chromosome 15
25.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:58941244-59082026 bp, - strand
From Ensembl annotation of GRCm38

  140783 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8841  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: metastasis suppressor protein 1
Gene Tree: Mtss1

Human
homologs
Human Homolog MTSS1, metastasis suppressor 1
NCBI Gene ID 9788
neXtProt AC  NX_O43312
Human Synonyms  MIM, MIMA, MIMB
Human Chr (Location)  8p22; chr8:124550770-124728507 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(187) : Gene trapped(181) Radiation induced(1) Targeted(5)
Genomic Mutations involving Mtss1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit polycystic kidney in 50% of mice by 5 months of age. Mouse embryonic fibroblasts from mice homozygous for a different gene trap allele exhibit altered cell morphology and physiology.
 
Human Diseases Modeled Using Mouse Mtss1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Mtss1 interacts with 353 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process actin cytoskeleton organization, actin filament organization, ...
Component actin cytoskeleton, adherens junction, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (42)    Tissues (41)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 30
Northern blot 12
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000022353 (Evidence)
Entrez Gene211401 (Evidence)
DFCITC1580628, TC1600998, TC1600849, TC1598387, TC1605119, TC1611397, TC1639969
DoTSDT.534378, DT.110814576, DT.101741330, DT.101708872, DT.101382308, DT.94206095, DT.60102612, DT.94406247, DT.97339976
NIA Mouse Gene IndexU328720, U084230
PDB2D1L
Consensus CDS ProjectCCDS27496.1
International Mouse Knockout Project StatusMtss1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022353 Ensembl Gene Model | MGI Sequence Detail 140783 C57BL/6J ±  kb
transcript ENSMUST00000080371 Ensembl | MGI Sequence Detail 4965 Not Applicable 
polypeptide ENSMUSP00000079239 Ensembl | MGI Sequence Detail 759 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(28) UniProt(5)
Polymorphisms
SNPs within 2kb(954 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013606 IRSp53/MIM homology domain (IMD)
InterPro IPR003124 WH2 domain
Protein Ontology PR:000010751 metastasis suppressor protein 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194840 Atwood SX, et al., GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas. Nature. 2013 Feb 28;494(7438):484-8
All references(49)
Disease annotation references (1)
Other
accession IDs
MGI:1917337, MGI:2442868

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory