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Mtss1
Gene Detail
Symbol

Name
ID
Mtss1
metastasis suppressor 1
MGI:2384818
Synonyms
2310003N14Rik, D130001D01Rik, MGC:37896, MIM, mKIAA0429
Feature Type
protein coding gene
Genetic Map
Chromosome 15
25.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:58941244-59082026 bp, - strand
From Ensembl annotation of GRCm38

  140783 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8841  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MTSS1
Protein SuperFamily: metastasis suppressor protein 1
Gene Tree: Mtss1

Human
homologs
MTSS1, metastasis suppressor 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9788
neXtProt AC: NX_O43312

Human Synonyms: MIM, MIMA, MIMB

Human Chr (Location): 8p22; chr8:124550770-124728507 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(185) : Gene trapped(179) Radiation induced(1) Targeted(5)
Genomic Mutations involving Mtss1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trap allele exhibit polycystic kidney in 50% of mice by 5 months of age. Mouse embryonic fibroblasts from mice homozygous for a different gene trap allele exhibit altered cell morphology and physiology.
 
Human Diseases Modeled in Mice Using Mtss1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Mtss1 interacts with 353 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process actin cytoskeleton organization, actin filament organization, ...
Component actin cytoskeleton, adherens junction, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (42)    Tissues (41)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 30
Northern blot 12
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100492573, mtss1.1    NEW 
Molecular
reagents
All nucleic(13) cDNA(12) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000022353 (Evidence)
Entrez Gene 211401 (Evidence)
DFCI TC1580628, TC1598387, TC1600849, TC1600998, TC1605119, TC1611397, TC1639969
DoTS DT.101382308, DT.101708872, DT.101741330, DT.110814576, DT.534378, DT.60102612, DT.94206095, DT.94406247, DT.97339976
NIA Mouse Gene Index U084230, U328720
PDB 2D1L
Consensus CDS Project CCDS27496.1
International Mouse Phenotyping Consortium Status Mtss1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022353 Ensembl Gene Model | MGI Sequence Detail 140783 C57BL/6J ±  kb
transcript ENSMUST00000080371 Ensembl | MGI Sequence Detail 4965 Not Applicable 
polypeptide ENSMUSP00000079239 Ensembl | MGI Sequence Detail 759 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(34) UniProt(3)
Polymorphisms
SNPs within 2kb(954 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013606 IRSp53/MIM homology domain (IMD)
InterPro IPR003124 WH2 domain
Protein Ontology PR:000010751 metastasis suppressor protein 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194840 Atwood SX, et al., GLI activation by atypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas. Nature. 2013 Feb 28;494(7438):484-8
All references(47)
Disease annotation references (1)
Other
accession IDs
MGI:1917337, MGI:2442868

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory