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Lpcat1 Gene Detail
Summary
  • Symbol
    Lpcat1
  • Name
    lysophosphatidylcholine acyltransferase 1
  • Synonyms
    2900035H07Rik, Aytl2, LPCAT, MGC:8148, rd11
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384812
    NCBI Gene: 210992
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:73467209-73516420 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 39.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    240 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384812
protein coding gene Chr13:73467197-73516422 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020745
protein coding gene Chr13:73916129-73965321 (+)
A/J MGP_AJ_G0020701
protein coding gene Chr13:71287960-71337607 (+)
AKR/J MGP_AKRJ_G0020675
protein coding gene Chr13:73528528-73578822 (+)
BALB/cJ MGP_BALBcJ_G0020698
protein coding gene Chr13:71779071-71828209 (+)
C3H/HeJ MGP_C3HHeJ_G0020492
protein coding gene Chr13:73209602-73259776 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021135
protein coding gene Chr13:76391099-76441574 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018702
protein coding gene Chr13:68103070-68157368 (+)
CAST/EiJ MGP_CASTEiJ_G0020009
protein coding gene Chr13:72284683-72338085 (+)
CBA/J MGP_CBAJ_G0020451
protein coding gene Chr13:79230930-79282449 (+)
DBA/2J MGP_DBA2J_G0020576
protein coding gene Chr13:71107436-71156859 (+)
FVB/NJ MGP_FVBNJ_G0020556
protein coding gene Chr13:70130122-70179321 (+)
LP/J MGP_LPJ_G0020649
protein coding gene Chr13:74163507-74213364 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020584
protein coding gene Chr13:77668578-77718816 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021174
protein coding gene Chr13:72834863-72885318 (+)
PWK/PhJ MGP_PWKPhJ_G0019763
protein coding gene Chr13:69840570-69892003 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019586
protein coding gene Chr13:69298818-69349357 (+)
WSB/EiJ MGP_WSBEiJ_G0020067
protein coding gene Chr13:73382192-73432831 (+)



Homology
more
  • Human Ortholog
    LPCAT1, lysophosphatidylcholine acyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LPCAT1, lysophosphatidylcholine acyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGPAT10, AGPAT9, AYTL2, lpcat, LPCAT-1, lysoPAFAT, PFAAP3
  • Links
    NCBI Gene ID: 79888
    neXtProt AC: NX_Q8NF37
    UniProt: Q8NF37

  • Chr Location
    5p15.33; chr5:1461427-1523961 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9871
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LPCAT1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Some mice homozygous for a gene trapped allele exhibit neonatal lethality associated with respiratory distress, cyanosis, atelectasis, lung hemorrhage, and defective surfactant function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 210992 NCBI Gene Model | MGI Sequence Detail 49212 C57BL/6J ±  kb
    transcript NM_145376 RefSeq | MGI Sequence Detail 1605 Not Specified  
    polypeptide Q3TFD2 UniProt | EBI | MGI Sequence Detail 534 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1923850, MGI:2142294, MGI:2145536, MGI:2157071
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 9
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:252290 Dai X, et al., Effects of Subretinal Gene Transfer at Different Time Points in a Mouse Model of Retinal Degeneration. PLoS One. 2016;11(5):e0156542

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory