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Lpcat1
Gene Detail
 Symbol
Name
ID
Lpcat1
lysophosphatidylcholine acyltransferase 1
MGI:2384812
Synonyms 2900035H07Rik, Aytl2, LPCAT, MGC:8148, rd11
Feature Type protein coding gene
Genetic Map
Chromosome 13
39.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:73467197-73516422 bp, + strand
From VEGA annotation of GRCm38

  49226 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9871  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lpcat1

Human
homologs
Human Homolog LPCAT1, lysophosphatidylcholine acyltransferase 1
NCBI Gene ID 79888
neXtProt AC  NX_Q8NF37
Human Synonyms  AYTL2, lpcat, PFAAP3
Human Chr (Location)  5p15.33; chr5:1461427-1523961 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Spontaneous(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Some mice homozygous for a gene trapped allele exhibit neonatal lethality associated with respiratory distress, cyanosis, atelectasis, lung hemorrhage, and defective surfactant function.
 
Interactions
Lpcat1 interacts with 279 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process lipid metabolic process, metabolic process, ...
Component endoplasmic reticulum, Golgi apparatus, ...
Function 1-acylglycerophosphocholine O-acyltransferase activity, 1-alkenylglycerophosphocholine O-acyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (39)    Tissues (14)    Images (3)
Theiler Stages: 20, 22, 24, 26, 27, 28
Assay TypeResults
RNA in situ 15
Western blot 3
RT-PCR 21
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000033733 (Evidence)
Ensembl Gene ModelENSMUSG00000021608 (Evidence)
Entrez Gene210992 (Evidence)
DFCITC1574098, TC1593450, TC1635039
DoTSDT.101741345, DT.101741346, DT.492425
NIA Mouse Gene IndexU014998
EC2.3.1.23, 2.3.1.67
Consensus CDS ProjectCCDS36726.1
International Mouse Knockout Project StatusLpcat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033733 VEGA Gene Model | MGI Sequence Detail 49226 C57BL/6J ±  kb
transcript OTTMUST00000084977 VEGA | MGI Sequence Detail 3675 Not Applicable 
polypeptide OTTMUSP00000045858 VEGA | MGI Sequence Detail 534 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(244 from dbSNP Build 137)    SNPs within 2kb including multiple locations(246)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR002123 Phospholipid/glycerol acyltransferase
Protein Ontology PR:000009890 lysophosphatidylcholine acyltransferase 1
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:198291 Huang Y, et al., Hypoxia inducible factor 3alpha plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development. PLoS One. 2013;8(2):e57695
All references(44)
Other
accession IDs
MGI:1923850, MGI:2142294, MGI:2145536, MGI:2157071

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory