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Lpcat1
Gene Detail
Symbol

Name
ID
Lpcat1
lysophosphatidylcholine acyltransferase 1
MGI:2384812
Synonyms
2900035H07Rik, Aytl2, LPCAT, MGC:8148, rd11
Feature Type
protein coding gene
Genetic Map
Chromosome 13
39.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:73467197-73516422 bp, + strand
From VEGA annotation of GRCm38

  49226 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9871  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LPCAT1
Gene Tree: Lpcat1

Human
homologs
LPCAT1, lysophosphatidylcholine acyltransferase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79888
neXtProt AC: NX_Q8NF37

Human Synonyms: AYTL2, lpcat, PFAAP3

Human Chr (Location): 5p15.33; chr5:1461427-1525730 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Spontaneous(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Some mice homozygous for a gene trapped allele exhibit neonatal lethality associated with respiratory distress, cyanosis, atelectasis, lung hemorrhage, and defective surfactant function.
 
Interactions
Lpcat1 interacts with 278 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (39)    Tissues (14)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 15
Western blot 3
RT-PCR 21
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lpcat1    NEW 
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000033733 (Evidence)
Ensembl Gene Model ENSMUSG00000021608 (Evidence)
Entrez Gene 210992 (Evidence)
DFCI TC1574098, TC1593450, TC1635039
DoTS DT.101741345, DT.101741346, DT.492425
NIA Mouse Gene Index U014998
EC 2.3.1.23, 2.3.1.67
Consensus CDS Project CCDS36726.1
International Mouse Phenotyping Consortium Status Lpcat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033733 VEGA Gene Model | MGI Sequence Detail 49226 C57BL/6J ±  kb
transcript OTTMUST00000084977 VEGA | MGI Sequence Detail 3675 Not Applicable 
polypeptide OTTMUSP00000045858 VEGA | MGI Sequence Detail 534 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(10) UniProt(4)
Polymorphisms
SNPs within 2kb(244 from dbSNP Build 137)    SNPs within 2kb including multiple locations(246)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR002123 Phospholipid/glycerol acyltransferase
Protein Ontology PR:000009890 lysophosphatidylcholine acyltransferase 1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:198291 Huang Y, et al., Hypoxia inducible factor 3alpha plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development. PLoS One. 2013;8(2):e57695
All references(42)
Other
accession IDs
MGI:1923850, MGI:2142294, MGI:2145536, MGI:2157071

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory