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Metrnl Gene Detail
Summary
  • Symbol
    Metrnl
  • Name
    meteorin, glial cell differentiation regulator-like
  • Synonyms
    9430048M07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384806
    NCBI Gene: 210029
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:121701544-121716306 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 86.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384806
protein coding gene Chr11:121701544-121717389 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019553
protein coding gene Chr11:126255619-126269132 (+)
A/J MGP_AJ_G0019520
protein coding gene Chr11:120608006-120621522 (+)
AKR/J MGP_AKRJ_G0019490
protein coding gene Chr11:124275668-124289171 (+)
BALB/cJ MGP_BALBcJ_G0019495
protein coding gene Chr11:120989681-121003199 (+)
C3H/HeJ MGP_C3HHeJ_G0019301
protein coding gene Chr11:124603594-124617104 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019944
protein coding gene Chr11:130081781-130095295 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017569
protein coding gene Chr11:117600386-117614161 (+)
CAST/EiJ MGP_CASTEiJ_G0018855
protein coding gene Chr11:126086758-126129952 (+)
CBA/J MGP_CBAJ_G0019272
protein coding gene Chr11:135130721-135144153 (+)
DBA/2J MGP_DBA2J_G0019385
protein coding gene Chr11:119999885-120013370 (+)
FVB/NJ MGP_FVBNJ_G0019376
protein coding gene Chr11:119724386-119737883 (+)
LP/J MGP_LPJ_G0019456
protein coding gene Chr11:126538607-126552125 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019409
protein coding gene Chr11:133929630-133943103 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019983
protein coding gene Chr11:124964928-124978440 (+)
PWK/PhJ MGP_PWKPhJ_G0018622
protein coding gene Chr11:121432987-121470312 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018413
protein coding gene Chr11:124699539-124713383 (+)
WSB/EiJ MGP_WSBEiJ_G0018908
protein coding gene Chr11:124923094-124941484 (+)



Homology
more
  • Human Ortholog
    METRNL, meteorin like, glial cell differentiation regulator
  • Vertebrate Orthologs
    11
  • Human Ortholog
    METRNL, meteorin like, glial cell differentiation regulator
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 284207
    neXtProt AC: NX_Q641Q3
    UniProt: Q641Q3

  • Chr Location
    17q25.3; chr17:83079691-83095126 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 16993
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: METRNL
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased LPS-induced mortality, altered Ig serum levels and inflammation in the uterus, kidney and liver.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039208 Ensembl Gene Model | MGI Sequence Detail 14763 C57BL/6J ±  kb
    transcript ENSMUST00000036742 Ensembl | MGI Sequence Detail 1401 Not Applicable  
    polypeptide ENSMUSP00000038126 Ensembl | MGI Sequence Detail 311 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 48

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2444092
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:268270 Ushach I, et al., Meteorin-like/Meteorin-beta Is a Novel Immunoregulatory Cytokine Associated with Inflammation. J Immunol. 2018 Dec 15;201(12):3669-3676

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    05/19/2020
    MGI 6.15
    The Jackson Laboratory