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Tbc1d12 Gene Detail
Summary
  • Symbol
    Tbc1d12
  • Name
    TBC1D12: TBC1 domain family, member 12
  • Synonyms
    MGC:38216
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384803
    NCBI Gene: 209478
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:38836579-38919923 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 33.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    353 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384803
protein coding gene Chr19:38836579-38919923 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025095
protein coding gene Chr19:37925211-38017440 (+)
A/J MGP_AJ_G0025071
protein coding gene Chr19:36087755-36171477 (+)
AKR/J MGP_AKRJ_G0025039
protein coding gene Chr19:37276156-37372097 (+)
BALB/cJ MGP_BALBcJ_G0025069
protein coding gene Chr19:36185632-36269348 (+)
C3H/HeJ MGP_C3HHeJ_G0024828
protein coding gene Chr19:37396701-37484374 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025510
protein coding gene Chr19:38999731-39087841 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022929
protein coding gene Chr19:35406038-35481680 (+)
CAST/EiJ MGP_CASTEiJ_G0024295
protein coding gene Chr19:37253193-37349822 (+)
CBA/J MGP_CBAJ_G0024805
protein coding gene Chr19:40837258-40956702 (+)
DBA/2J MGP_DBA2J_G0024937
protein coding gene Chr19:35920951-36006408 (+)
FVB/NJ MGP_FVBNJ_G0024898
protein coding gene Chr19:35752364-35834905 (+)
LP/J MGP_LPJ_G0025023
protein coding gene Chr19:38007778-38096189 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024929
protein coding gene Chr19:40566569-40663543 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025568
protein coding gene Chr19:37408908-37500299 (+)
PWK/PhJ MGP_PWKPhJ_G0024047
protein coding gene Chr19:35797541-35883434 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023847
protein coding gene Chr19:36242768-36328136 (+)
WSB/EiJ MGP_WSBEiJ_G0024362
protein coding gene Chr19:37497561-37583621 (+)



Homology
more
  • Human Ortholog
    TBC1D12, TBC1 domain family member 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TBC1D12, TBC1 domain family member 12
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23232
    neXtProt AC: NX_O60347
    UniProt: O60347

  • Chr Location
    10q23.33; chr10:94402429-94536332 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 209478 NCBI Gene Model | MGI Sequence Detail 83345 C57BL/6J ±  kb
transcript NM_145952 RefSeq | MGI Sequence Detail 3956 C57BL/6  
polypeptide Q6A039 UniProt | EBI | MGI Sequence Detail 696 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR000195 Rab-GTPase-TBC domain
    IPR035969 Rab-GTPase-TBC domain superfamily
Molecular
Reagents
less
  • All nucleic 28
    cDNA 28

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory