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Gps1 Gene Detail
Summary
  • Symbol
    Gps1
  • Name
    G protein pathway suppressor 1
  • Synonyms
    COPS1, Csn1, MGC:7191
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384801
    NCBI Gene: 209318
  • Gene Overview
    MyGene.info: GPS1
Location & Maps
more
  • Sequence Map
    Chr11:120784272-120789102 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4831 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 84.54 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GPS1, G protein pathway suppressor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPS1, G protein pathway suppressor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COPS1, CSN1, SGN1
  • Links
    NCBI Gene ID: 2873
    neXtProt AC: NX_Q13098

  • Chr Location
    17q25.3; chr17:82051351-82057470 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    2
  • Targeted
    3
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004142 VEGA Gene Model | MGI Sequence Detail 4831 C57BL/6J ±  kb
transcript OTTMUST00000009373 VEGA | MGI Sequence Detail 2000 Not Applicable  
polypeptide OTTMUSP00000004561 VEGA | MGI Sequence Detail 526 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000008202 COP9 signalosome complex subunit 1
  • InterPro Domains
    IPR019585 26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1
    IPR033008 COP9 signalosome complex subunit 1
    IPR000717 Proteasome component (PCI) domain
    IPR011990 Tetratricopeptide-like helical domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144715
References
more
  • Summaries
    All 32
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:50270 Wei N, et al., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory