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Gps1 Gene Detail
Summary
  • Symbol
    Gps1
  • Name
    G protein pathway suppressor 1
  • Synonyms
    COPS1, Csn1, MGC:7191
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384801
    NCBI Gene: 209318
  • Gene Overview
    MyGene.info: GPS1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120784272-120789102 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 84.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384801
protein coding gene Chr11:120784260-120789102 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019529
protein coding gene Chr11:125277440-125288121 (+)
A/J MGP_AJ_G0019496
protein coding gene Chr11:119696255-119701089 (+)
AKR/J MGP_AKRJ_G0019466
protein coding gene Chr11:123315783-123320443 (+)
BALB/cJ MGP_BALBcJ_G0019471
protein coding gene Chr11:120052122-120058090 (+)
C3H/HeJ MGP_C3HHeJ_G0019277
protein coding gene Chr11:123643706-123650287 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019920
protein coding gene Chr11:129068942-129092851 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017545
protein coding gene Chr11:116684763-116689569 (+)
CAST/EiJ MGP_CASTEiJ_G0018831
protein coding gene Chr11:125146131-125150975 (+)
CBA/J MGP_CBAJ_G0019248
protein coding gene Chr11:134101083-134105954 (+)
DBA/2J MGP_DBA2J_G0019361
protein coding gene Chr11:119065506-119074200 (+)
FVB/NJ MGP_FVBNJ_G0019352
protein coding gene Chr11:118779873-118787925 (+)
LP/J MGP_LPJ_G0019432
protein coding gene Chr11:125571943-125581329 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019385
protein coding gene Chr11:132930987-132938483 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019959
protein coding gene Chr11:123981757-123989758 (+)
PWK/PhJ MGP_PWKPhJ_G0018597
protein coding gene Chr11:120504363-120509367 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018389
protein coding gene Chr11:123749811-123754631 (+)
WSB/EiJ MGP_WSBEiJ_G0018884
protein coding gene Chr11:123976081-123981000 (+)



Homology
more
  • Human Ortholog
    GPS1, G protein pathway suppressor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPS1, G protein pathway suppressor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COPS1, CSN1, SGN1
  • Links
    NCBI Gene ID: 2873
    neXtProt AC: NX_Q13098
    UniProt: Q13098

  • Chr Location
    17q25.3; chr17:82051477-82057470 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025156 Ensembl Gene Model | MGI Sequence Detail 4831 C57BL/6J ±  kb
    transcript ENSMUST00000172809 Ensembl | MGI Sequence Detail 2000 Not Applicable  
    polypeptide ENSMUSP00000133855 Ensembl | MGI Sequence Detail 526 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR019585 26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1
      IPR033008 COP9 signalosome complex subunit 1
      IPR000717 Proteasome component (PCI) domain
      IPR036390 Winged helix DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144715
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:50270 Wei N, et al., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory