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Fanci Gene Detail
Summary
  • Symbol
    Fanci
  • Name
    Fanconi anemia, complementation group I
  • Synonyms
    MGC:38195, MGC:38407
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384790
    NCBI Gene: 208836
  • Gene Overview
    MyGene.info: FANCI
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:79392312-79450265 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.01 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    475 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384790
protein coding gene Chr7:79391929-79450265 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032388
protein coding gene Chr7:81273939-81335209 (+)
A/J MGP_AJ_G0032367
protein coding gene Chr7:79398227-79457525 (+)
AKR/J MGP_AKRJ_G0032303
protein coding gene Chr7:81096937-81158645 (+)
BALB/cJ MGP_BALBcJ_G0032379
protein coding gene Chr7:79096316-79154860 (+)
C3H/HeJ MGP_C3HHeJ_G0032092
protein coding gene Chr7:81765261-81824926 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032871
protein coding gene Chr7:84473354-84532804 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029879
protein coding gene Chr7:81941933-82003296 (+)
CAST/EiJ MGP_CASTEiJ_G0031420
protein coding gene Chr7:72630585-72692466 (+)
CBA/J MGP_CBAJ_G0032058
protein coding gene Chr7:87297967-87365069 (+)
DBA/2J MGP_DBA2J_G0032213
protein coding gene Chr7:77976374-78035500 (+)
FVB/NJ MGP_FVBNJ_G0032168
protein coding gene Chr7:77887828-77947016 (+)
LP/J MGP_LPJ_G0032294
protein coding gene Chr7:82525534-82585987 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032205
protein coding gene Chr7:87490040-87551963 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032889
protein coding gene Chr7:80552362-80614527 (+)
PWK/PhJ MGP_PWKPhJ_G0031140
protein coding gene Chr7:71140663-71200121 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030981
protein coding gene Chr7:67541317-67603743 (+)
WSB/EiJ MGP_WSBEiJ_G0031538
protein coding gene Chr7:80874124-80933078 (+)



Homology
more
  • Human Ortholog
    FANCI, FA complementation group I
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FANCI, FA complementation group I
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIAA1794
  • Links
    NCBI Gene ID: 55215
    neXtProt AC: NX_Q9NVI1
    UniProt: Q9NVI1

  • Chr Location
    15q26.1; chr15:89243954-89317132 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 49530
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FANCI
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human FANCI associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 208836 NCBI Gene Model | MGI Sequence Detail 57954 C57BL/6J ±  kb
transcript NM_145946 RefSeq | MGI Sequence Detail 4621 C57BL/6  
polypeptide Q8K368 UniProt | EBI | MGI Sequence Detail 1330 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 20
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:241332 Chen HR, et al., Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex. Cereb Cortex. 2017 Mar 01;27(3):2289-2302

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory