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Rapgef6
Gene Detail
 Symbol
Name
ID
Rapgef6
Rap guanine nucleotide exchange factor (GEF) 6
MGI:2384761
Synonyms C030018K18Rik, Pdzgef2, PDZ-GEF2, RA-GEF-2
Feature Type protein coding gene
Genetic Map
Chromosome 11
32.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:54522847-54699285 bp, + strand
From VEGA annotation of GRCm38

  176439 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22968  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rapgef6

Human
homologs
Human Homolog RAPGEF6, Rap guanine nucleotide exchange factor (GEF) 6
NCBI Gene ID 51735
neXtProt AC  NX_Q8TEU7
Human Synonyms  KIA001LB, PDZGEF2, PDZ-GEF2, RAGEF2, RA-GEF-2
Human Chr (Location)  5q31.1; chr5:131423921-131635236 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(18) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit an inlarged spleen, increased IgE and IgG levels and altered cytokine production.
 
Interactions
Rapgef6 interacts with 414 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process positive regulation of GTPase activity
Component plasma membrane
Function GTP-dependent protein binding, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (83)    Tissues (13)    Images (19)
Theiler Stages: 23
Assay TypeResults
RNA in situ 83
cDNA source data(113)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(113) cDNA(113)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000005672 (Evidence)
Ensembl Gene ModelENSMUSG00000037533 (Evidence)
Entrez Gene192786 (Evidence)
UniGene254404
DFCITC1586214, TC1597579, TC1601764, TC1602252, TC1605172, TC1606910, TC1617918, TC1619828, TC1624160
DoTSDT.101279667, DT.101357493, DT.101384307, DT.101735358, DT.40172053, DT.492277, DT.91328550, DT.91331653, DT.91338657, DT.91358017, DT.91553401, DT.94123287
NIA Mouse Gene IndexU012611
Consensus CDS ProjectCCDS24699.1
International Mouse Knockout Project StatusRapgef6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005672 VEGA Gene Model | MGI Sequence Detail 176439 C57BL/6J ±  kb
transcript OTTMUST00000012624 VEGA | MGI Sequence Detail 5864 Not Applicable 
polypeptide OTTMUSP00000005849 VEGA | MGI Sequence Detail 1609 Not Applicable 

For the selected sequences
All sequences(130) RefSeq(28) UniProt(16)
Polymorphisms SNPs within 2kb(390 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR001895 Guanine-nucleotide dissociation stimulator CDC25
InterPro IPR001478 PDZ domain
InterPro IPR000159 Ras-association
InterPro IPR023578 Ras guanine nucleotide exchange factor, domain
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000013731 rap guanine nucleotide exchange factor 6
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(37)
Other
accession IDs
MGI:1924777, MGI:2144285, MGI:2144597

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory