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Rapgef6
Gene Detail
Symbol

Name
ID
Rapgef6
Rap guanine nucleotide exchange factor (GEF) 6
MGI:2384761
Synonyms
C030018K18Rik, Pdzgef2, PDZ-GEF2, RA-GEF-2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
32.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:54522847-54699285 bp, + strand
From VEGA annotation of GRCm38

  176439 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22968  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: RAPGEF6
Gene Tree: Rapgef6

Human
homologs
RAPGEF6, Rap guanine nucleotide exchange factor (GEF) 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51735
neXtProt AC: NX_Q8TEU7

Human Synonyms: KIA001LB, PDZGEF2, PDZ-GEF2, RAGEF2, RA-GEF-2

Human Chr (Location): 5q31.1; chr5:131423921-131635236 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(18) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit an inlarged spleen, increased IgE and IgG levels and altered cytokine production.
 
Interactions
Rapgef6 interacts with 413 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process microvillus assembly, positive regulation of GTPase activity, ...
Component apical plasma membrane, cytosol, ...
Function GTP-dependent protein binding, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (85)    Tissues (14)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 83
RT-PCR 2
cDNA source data(113)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rapgef6    NEW 
Molecular
reagents
All nucleic(114) cDNA(113) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000005672 (Evidence)
Ensembl Gene Model ENSMUSG00000037533 (Evidence)
Entrez Gene 192786 (Evidence)
UniGene 254404
DFCI TC1624160, TC1606910, TC1619828, TC1605172, TC1586214, TC1602252, TC1617918, TC1597579, TC1601764
DoTS DT.101735358, DT.492277, DT.40172053, DT.101384307, DT.101357493, DT.101279667, DT.94123287, DT.91328550, DT.91553401, DT.91331653, DT.91358017, DT.91338657
NIA Mouse Gene Index U012611
Consensus CDS Project CCDS24699.1
International Mouse Phenotyping Consortium Status Rapgef6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005672 VEGA Gene Model | MGI Sequence Detail 176439 C57BL/6J ±  kb
transcript OTTMUST00000012624 VEGA | MGI Sequence Detail 5864 Not Applicable 
polypeptide OTTMUSP00000005849 VEGA | MGI Sequence Detail 1609 Not Applicable 

For the selected sequences
All sequences(130) RefSeq(28) UniProt(16)
Polymorphisms
SNPs within 2kb(390 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR001895 Guanine-nucleotide dissociation stimulator CDC25
InterPro IPR001478 PDZ domain
InterPro IPR000159 Ras-association
InterPro IPR023578 Ras guanine nucleotide exchange factor, domain
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000013731 rap guanine nucleotide exchange factor 6
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218581 Okada K, et al., Critical function of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in mouse spermatogenesis. Biochem Biophys Res Commun. 2014 Feb 28;445(1):89-94
All references(36)
Other
accession IDs
MGI:1924777, MGI:2144285, MGI:2144597

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory