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Rapgef6
Gene Detail
Symbol

Name
ID
Rapgef6
Rap guanine nucleotide exchange factor (GEF) 6
MGI:2384761
Synonyms
C030018K18Rik, Pdzgef2, PDZ-GEF2, RA-GEF-2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
32.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:54522847-54699285 bp, + strand
From VEGA annotation of GRCm38

  176439 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22968  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rapgef6

Human
homologs
Human Homolog RAPGEF6, Rap guanine nucleotide exchange factor (GEF) 6
NCBI Gene ID 51735
neXtProt AC  NX_Q8TEU7
Human Synonyms  KIA001LB, PDZGEF2, PDZ-GEF2, RAGEF2, RA-GEF-2
Human Chr (Location)  5q31.1; chr5:131423921-131635236 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(18) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit an inlarged spleen, increased IgE and IgG levels and altered cytokine production.
 
Interactions
Rapgef6 interacts with 414 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process positive regulation of GTPase activity
Component plasma membrane
Function GTP-dependent protein binding, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (83)    Tissues (13)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 83
cDNA source data(113)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(113) cDNA(113)
Microarray probesets(6)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005672 VEGA Gene Model | MGI Sequence Detail 176439 C57BL/6J ±  kb
transcript OTTMUST00000012624 VEGA | MGI Sequence Detail 5864 Not Applicable 
polypeptide OTTMUSP00000005849 VEGA | MGI Sequence Detail 1609 Not Applicable 

For the selected sequences
All sequences(146) RefSeq(28) UniProt(32)
Polymorphisms
SNPs within 2kb(390 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR001895 Guanine-nucleotide dissociation stimulator CDC25
InterPro IPR001478 PDZ domain
InterPro IPR000159 Ras-association
InterPro IPR023578 Ras guanine nucleotide exchange factor, domain
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000013731 rap guanine nucleotide exchange factor 6
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(37)
Other
accession IDs
MGI:1924777, MGI:2144285, MGI:2144597

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory