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Phf21a
Gene Detail
 Symbol
Name
ID
Phf21a
PHD finger protein 21A
MGI:2384756
Synonyms 80kDa, Bhc80, Braf35/HDAC complex (Bhc), D030065N23Rik, MGC:29190, PFTF1
Feature Type protein coding gene
Genetic Map
Chromosome 2
50.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:92184106-92361835 bp, + strand
From VEGA annotation of GRCm38

  177730 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9597  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: BRAF-HDAC complex, BHC80 subunit
Gene Tree: Phf21a

Human
homologs
Human Homolog PHF21A, PHD finger protein 21A
NCBI Gene ID 51317
neXtProt AC  NX_Q96BD5
Human Synonyms  BHC80
Human Chr (Location)  11p11.2; chr11:45929319-46121434 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(180) : Gene trapped(177) Targeted(3)
Genomic Mutations involving Phf21a (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit neonatal lethality and insufficient milk-sucking behavior.
 
Interactions
Phf21a interacts with 382 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process chromatin modification, negative regulation of transcription from RNA polymerase II promoter, ...
Component histone deacetylase complex, nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (86)    Tissues (60)    Images (11)
Theiler Stages: 2, 3, 4, 5, 17, 21, 22, 23, 28
Assay TypeResults
RNA in situ 78
RT-PCR 8
cDNA source data(76)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) cDNA(77) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000014393 (Evidence)
Ensembl Gene ModelENSMUSG00000058318 (Evidence)
Entrez Gene192285 (Evidence)
UniGene330408
DFCITC1580885, TC1589222, TC1591365, TC1612524, TC1630090, TC1636296, TC1744080, TC1744441
DoTSDT.101215533, DT.101341348, DT.110657493, DT.110657515, DT.50316167, DT.524458, DT.55219822, DT.91416932, DT.91423954
NIA Mouse Gene IndexU002134
Consensus CDS ProjectCCDS16442.1, CCDS50644.1, CCDS50645.1
International Mouse Knockout Project StatusPhf21a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014393 VEGA Gene Model | MGI Sequence Detail 177730 C57BL/6J ±  kb
transcript OTTMUST00000034055 VEGA | MGI Sequence Detail 3900 Not Applicable 
polypeptide OTTMUSP00000015256 VEGA | MGI Sequence Detail 688 Not Applicable 

For the selected sequences
All sequences(173) RefSeq(50) UniProt(16)
Polymorphisms SNPs within 2kb(739 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017956 AT hook, DNA-binding motif
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR019786 Zinc finger, PHD-type, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000012648 PHD finger protein 21A
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:203593 Kim HG, et al., Translocations disrupting PHF21A in the Potocki-Shaffer-syndrome region are associated with intellectual disability and craniofacial anomalies. Am J Hum Genet. 2012 Jul 13;91(1):56-72
All references(48)
Other
accession IDs
MGI:3026971

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory