Phf21a
Gene Detail

Symbol Name ID

Phf21a PHD finger protein 21A MGI:2384756

Synonyms

80kDa, Bhc80, Braf35/HDAC complex (Bhc), D030065N23Rik, MGC:29190, PFTF1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

50.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:92184106-92361835 bp, + strand From VEGA annotation of GRCm38   177730 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9597  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: BRAF-HDAC complex, BHC80 subunit
Gene Tree: Phf21a

Human homologs

Human Homolog		PHF21A, PHD finger protein 21A
NCBI Gene ID		51317
neXtProt AC		NX_Q96BD5
Human Synonyms		BHC80
Human Chr (Location)		11p11.2; chr11:45950870-46142985 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(178) : Targeted(1) Gene trapped(177)
 

Mice homozygous for a knock-out allele exhibit neonatal lethality and insufficient milk-sucking behavior.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	chromatin modification, negative regulation of transcription from RNA polymerase II promoter, ...
Component	histone deacetylase complex, nucleus
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (93)    Tissues (65)    Images (11)
Theiler Stages: 2, 3, 4, 5, 17, 21, 22, 23, 28

Assay Type	Results
RNA in situ	78
RT-PCR	15

cDNA source data(77)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(79) cDNA(78) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000014393 (Evidence)
Ensembl Gene Model	ENSMUSG00000058318 (Evidence)
Entrez Gene	192285 (Evidence)
UniGene	330408
DFCI	TC1580885, TC1589222, TC1591365, TC1612524, TC1630090, TC1636296, TC1744080, TC1744441
DoTS	DT.101215533, DT.101341348, DT.110657493, DT.110657515, DT.50316167, DT.524458, DT.55219822, DT.91416932, DT.91423954
NIA Mouse Gene Index	U002134
Consensus CDS Project	CCDS16442.1, CCDS50644.1, CCDS50645.1
International Mouse Knockout Project Status	Phf21a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014393	VEGA Gene Model | MGI Sequence Detail	177730	C57BL/6J
transcript	OTTMUST00000034055	VEGA | MGI Sequence Detail	3900	Not Applicable
polypeptide	OTTMUSP00000015256	VEGA | MGI Sequence Detail	688	Not Applicable

All sequences(129) RefSeq(6) UniProt(16)

Polymorphisms

SNPs(527 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017956	AT hook, DNA-binding motif
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR019787	Zinc finger, PHD-finger
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR019786	Zinc finger, PHD-type, conserved site
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
Protein Ontology	PR:000012648	PHD finger protein 21A

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(47)

Other accession IDs

MGI:3026971