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Mcrip1 Gene Detail
Summary
  • Symbol
    Mcrip1
  • Name
    MAPK regulated corepressor interacting protein 1
  • Synonyms
    BC003940, Fam195b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384752
    NCBI Gene: 192173
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120433714-120440553 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.25 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384752
 protein coding gene Chr11:120433714-120440553 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019508
 protein coding gene Chr11:125011993-125018860 (-)
A/J MGP_AJ_G0019476
 protein coding gene Chr11:119451950-119458824 (-)
AKR/J MGP_AKRJ_G0019446
 protein coding gene Chr11:123045603-123052186 (-)
BALB/cJ MGP_BALBcJ_G0019451
 protein coding gene Chr11:119807315-119814145 (-)
C3H/HeJ MGP_C3HHeJ_G0019257
 protein coding gene Chr11:123383459-123389947 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019899
 protein coding gene Chr11:128792876-128802639 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017525
 protein coding gene Chr11:116443219-116450637 (-)
CAST/EiJ MGP_CASTEiJ_G0018811
 protein coding gene Chr11:124873715-124883546 (-)
CBA/J MGP_CBAJ_G0019228
 protein coding gene Chr11:133836620-133843490 (-)
DBA/2J MGP_DBA2J_G0019340
 protein coding gene Chr11:118821323-118828131 (-)
FVB/NJ MGP_FVBNJ_G0019332
 protein coding gene Chr11:118531366-118538859 (-)
LP/J MGP_LPJ_G0019412
 protein coding gene Chr11:125315889-125324194 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019365
 protein coding gene Chr11:132671615-132680358 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019939
 protein coding gene Chr11:123733114-123740879 (-)
PWK/PhJ MGP_PWKPhJ_G0018577
 protein coding gene Chr11:120254530-120262552 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018369
 protein coding gene Chr11:123494455-123501315 (-)
WSB/EiJ MGP_WSBEiJ_G0018863
 protein coding gene Chr11:123721294-123728137 (-)



Homology
more
  • Human Ortholog
    MCRIP1, MAPK regulated corepressor interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCRIP1, MAPK regulated corepressor interacting protein 1
  • Synonyms
    FAM195B, GRAN2, MCRIP
  • Links
    NCBI Gene ID: 348262
    neXtProt AC: NX_C9JLW8
    UniProt: C9JLW8

  • Chr Location
    17q25.3; chr17:81822361-81833302 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most mice homozygous for a knock-out allele die in the neonatal stage due to atelectasis and respiratory failure associated with decreased surfactant secretion and abnormal alveolar lamellar body morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    4
  • cDNA Data
    104
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 192173 NCBI Gene Model | MGI Sequence Detail 6840 C57BL/6J ±  kb
    transcript NM_001373934 RefSeq | MGI Sequence Detail 1689 C57BL/6  
    polypeptide Q3UGS4 UniProt | EBI | MGI Sequence Detail 97 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000032527 Mapk-regulated corepressor-interacting protein 1
      (term hierarchy)
    • InterPro Domains
      IPR029428 Mapk-regulated corepressor-interacting protein
    Molecular
    Reagents
    less
    • All nucleic 104
      cDNA 104

      Microarray probesets 3
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 5
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:278092 Weng JS, et al., MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing. Commun Biol. 2019;2:227
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory