Cdc42ep3 Gene Detail

Summary

• Symbol
  Cdc42ep3
• Name
  CDC42 effector protein (Rho GTPase binding) 3
• Synonyms
  3200001F04Rik, Borg2, Cep3, UB1

• Feature Type
  protein coding gene
• IDs
  MGI:2384718
  NCBI Gene: 260409
• Gene Overview
  MyGene.info: CDC42EP3

Location & Maps

• Sequence Map
  Chr17:79334025-79355091 bp, - strand
• From Ensembl annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    21067 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 17, 50.30 cM
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  CDC42EP3, CDC42 effector protein 3

• Vertebrate Orthologs
  10

• Human Ortholog
  CDC42EP3, CDC42 effector protein 3
  Orthology source: HomoloGene, HGNC
• Synonyms
  BORG2, CEP3, UB1
• Links
  HGNC:16943

  NCBI Gene ID: 10602

  neXtProt AC: NX_Q9UKI2

  UniProt: Q9UKI2

  
  
• Chr Location
  2p22.2; chr2:37641882-37672535 (-)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 4708
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: CDC42EP3
• Protein SuperFamily
  Cdc42 effector protein 3
• Gene Tree
  Cdc42ep3
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotype references
  

• All Mutations and Alleles
  115
• Gene trapped
  113
• Targeted
  2
• Incidental Mutations
  APF
• Find Mice (IMSR)
  87 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  12
• GO References
  4

• External Resources
  FuncBase

Expression

• cDNA Data
  43
• Literature Summary
  1

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase cdc42ep3
  ZFIN cdc42ep3

Interactions

• Cdc42ep3 interacts with 149 markers (Mir19b-1, Mir19b-2, Mir34a, ...) View All

Sequences &
Gene Models

• All Sequences
  21
• RefSeq
  4
• UniProt
  1
• CCDS
  CCDS28984.1
• UniGene
  140601

• Ensembl
  ENSMUSG00000036533 (Evidence)
• NCBI Gene
  260409

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000036533	Ensembl Gene Model | MGI Sequence Detail	21067	C57BL/6J
transcript	ENSMUST00000068958	Ensembl | MGI Sequence Detail	1967	Not Applicable
polypeptide	ENSMUSP00000067217	Ensembl | MGI Sequence Detail	254	Not Applicable

Polymorphisms

• SNPs within 2kb
  253 from dbSNP Build 142

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000005210 cdc42 effector protein 3
  (term hierarchy)
• InterPro Domains
  IPR029273 Cdc42 effector
  IPR000095 CRIB domain

Molecular
Reagents

• All nucleic 43

  cDNA 43

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:1915275, MGI:2146788

References

• Summaries
  All 32

  Developmental Gene Expression 1

  Gene Ontology 4

  Phenotypes 6
• Earliest
  J:65159 Joberty G, et al., The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol Cell Biol. 1999 Oct;19(10):6585-97
• Latest
  J:184159 Antypa M, et al., Differential gene expression in migratory streams of cortical interneurons. Eur J Neurosci. 2011 Nov;34(10):1584-94