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Ndrg4 Gene Detail
Summary
  • Symbol
    Ndrg4
  • Name
    N-myc downstream regulated gene 4
  • Synonyms
    D8Bwg1337e, MGC:7067, Ndr1-rs, Ndr4, SMAP-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384590
    NCBI Gene: 234593
  • Gene Overview
    MyGene.info: NDRG4
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:95676985-95715119 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 47.12 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    232 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384590
protein coding gene Chr8:95676980-95715119 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033991
protein coding gene Chr8:97170287-97221168 (+)
A/J MGP_AJ_G0033974
protein coding gene Chr8:93356439-93393990 (+)
AKR/J MGP_AKRJ_G0033900
protein coding gene Chr8:95937863-95974947 (+)
BALB/cJ MGP_BALBcJ_G0033966
protein coding gene Chr8:93448774-93487226 (+)
C3H/HeJ MGP_C3HHeJ_G0033676
protein coding gene Chr8:96640623-96678899 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034487
protein coding gene Chr8:100743328-100787212 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031428
protein coding gene Chr8:87157715-87195061 (+)
CAST/EiJ MGP_CASTEiJ_G0033008
protein coding gene Chr8:96227547-96267290 (+)
CBA/J MGP_CBAJ_G0033652
protein coding gene Chr8:104029292-104077531 (+)
DBA/2J MGP_DBA2J_G0033806
protein coding gene Chr8:92849247-92889380 (+)
FVB/NJ MGP_FVBNJ_G0033753
protein coding gene Chr8:91811619-91850861 (+)
LP/J MGP_LPJ_G0033898
protein coding gene Chr8:97311510-97353007 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033795
protein coding gene Chr8:106256012-106294212 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034505
protein coding gene Chr8:96095208-96132914 (+)
PWK/PhJ MGP_PWKPhJ_G0032710
protein coding gene Chr8:92215125-92253842 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032547
protein coding gene Chr8:94932704-94971830 (+)
WSB/EiJ MGP_WSBEiJ_G0033120
protein coding gene Chr8:96604214-96649112 (+)



Homology
more
  • Human Ortholog
    NDRG4, NDRG family member 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NDRG4, NDRG family member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDM1, SMAP8, SMAP-8
  • Links
    NCBI Gene ID: 65009
    neXtProt AC: NX_Q9ULP0
    UniProt: Q9ULP0

  • Chr Location
    16q21; chr16:58463645-58515403 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 23228
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NDRG4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit spatial learning deficits and increased susceptibility to ischemic brain injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 234593 NCBI Gene Model | MGI Sequence Detail 38135 C57BL/6J ±  kb
    transcript NM_001195006 RefSeq | MGI Sequence Detail 2966 C57BL/6  
    polypeptide Q8BTG7 UniProt | EBI | MGI Sequence Detail 352 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 130
      cDNA 127
      Primer pair 2
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-34121, MGD-MRK-37557, MGI:106427, MGI:108513, MGI:2142896
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:249291 Yang Q, et al., Uterine Expression of NDRG4 Is Induced by Estrogen and Up-Regulated during Embryo Implantation Process in Mice. PLoS One. 2016;11(5):e0155491

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory