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Ndrg4
Gene Detail
Symbol

Name
ID
Ndrg4
N-myc downstream regulated gene 4
MGI:2384590
Synonyms
D8Bwg1337e, MGC:7067, Ndr1-rs, Ndr4, SMAP-8
Feature Type
protein coding gene
Genetic Map
Chromosome 8
47.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:95676980-95715119 bp, + strand
From VEGA annotation of GRCm38

  38140 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23228  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NDRG4
Gene Tree: Ndrg4

Human
homologs
NDRG4, NDRG family member 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 65009
neXtProt AC: NX_Q9ULP0

Human Synonyms: BDM1, SMAP8, SMAP-8

Human Chr (Location): 16q21; chr16:58463645-58513619 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit spatial learning deficits and increased susceptibility to ischemic brain injury.
 
Interactions
Ndrg4 interacts with 386 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process brain development, cell migration involved in heart development, ...
Component basolateral plasma membrane, cell projection membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (295)    Tissues (141)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 285
RT-PCR 10
cDNA source data(125)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ndrg4 ; ZFIN ndrg4    NEW 
Molecular
reagents
All nucleic(129) cDNA(126) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000027408 (Evidence)
Ensembl Gene Model ENSMUSG00000036564 (Evidence)
Entrez Gene 234593 (Evidence)
UniGene 29846
DFCI TC1587160, TC1572927
DoTS DT.101313789, DT.531205, DT.101131251, DT.99858062
NIA Mouse Gene Index U009694
Consensus CDS Project CCDS22565.1, CCDS57634.1
International Mouse Phenotyping Consortium Status Ndrg4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027408 VEGA Gene Model | MGI Sequence Detail 38140 C57BL/6J ±  kb
transcript OTTMUST00000067797 VEGA | MGI Sequence Detail 3101 Not Applicable 
polypeptide OTTMUSP00000034174 VEGA | MGI Sequence Detail 404 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(234 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004142 Ndr
Protein Ontology PR:000011062 protein NDRG4
References
(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:217261 Benesh EC, et al., Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition. Mol Biol Cell. 2013 Nov;24(22):3496-510
All references(46)
Other
accession IDs
MGD-MRK-34121, MGD-MRK-37557, MGI:106427, MGI:108513, MGI:2142896

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory