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Neil3 Gene Detail
Summary
  • Symbol
    Neil3
  • Name
    nei like 3 (E. coli)
  • Synonyms
    MGC:27861, MGC:36916
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384588
    NCBI Gene: 234258
  • Gene Overview
    MyGene.info: NEIL3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:53586867-53639065 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 29.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    324 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384588
protein coding gene Chr8:53586867-53639065 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033609
protein coding gene Chr8:53179846-53233789 (-)
A/J MGP_AJ_G0033591
protein coding gene Chr8:50980660-51033537 (-)
AKR/J MGP_AKRJ_G0033516
protein coding gene Chr8:52397758-52448549 (-)
BALB/cJ MGP_BALBcJ_G0033588
protein coding gene Chr8:51206490-51257106 (-)
C3H/HeJ MGP_C3HHeJ_G0033297
protein coding gene Chr8:53106512-53157418 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034104
protein coding gene Chr8:55178525-55234770 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031052
protein coding gene Chr8:46857526-46908898 (-)
CAST/EiJ MGP_CASTEiJ_G0032623
protein coding gene Chr8:52700883-52753422 (-)
CBA/J MGP_CBAJ_G0033276
protein coding gene Chr8:57207403-57266654 (-)
DBA/2J MGP_DBA2J_G0033429
protein coding gene Chr8:50778426-50830066 (-)
FVB/NJ MGP_FVBNJ_G0033370
protein coding gene Chr8:50118776-50170616 (-)
LP/J MGP_LPJ_G0033517
protein coding gene Chr8:53171606-53222786 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033414
protein coding gene Chr8:58276419-58333348 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034122
protein coding gene Chr8:52706371-52760770 (-)
PWK/PhJ MGP_PWKPhJ_G0032331
protein coding gene Chr8:50312081-50364701 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032167
protein coding gene Chr8:51797721-51850862 (-)
WSB/EiJ MGP_WSBEiJ_G0032739
protein coding gene Chr8:52940260-52994793 (-)



Homology
more
  • Human Ortholog
    NEIL3, nei like DNA glycosylase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEIL3, nei like DNA glycosylase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FGP2, FPG2, hFPG2, hNEI3, NEI3, ZGRF3
  • Links
    NCBI Gene ID: 55247
    neXtProt AC: NX_Q8TAT5
    UniProt: Q8TAT5

  • Chr Location
    4q34.3; chr4:177309837-177362938 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10094
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NEIL3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased neurogenesis following hypoxia-ischemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 234258 NCBI Gene Model | MGI Sequence Detail 52199 C57BL/6J ±  kb
transcript NM_146208 RefSeq | MGI Sequence Detail 2271 C57BL/6  
polypeptide Q8K203 UniProt | EBI | MGI Sequence Detail 606 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 39
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2142547, MGI:2142872
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:251257 Olsen MB, et al., NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell Rep. 2017 Jan 3;18(1):82-92

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory