Gatad2a Gene Detail

Summary

• Symbol
  Gatad2a
• Name
  GATA zinc finger domain containing 2A
• Synonyms
  1110066C11Rik, MGC:29315, MGC:36975

• Feature Type
  protein coding gene
• IDs
  MGI:2384585
  NCBI Gene: 234366

Location & Maps

• Sequence Map
  Chr8:69907076-69996384 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    89309 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 8, 34.06 cM
• Mapping Data
  3 experiments

Homology

• Human Ortholog
  GATAD2A, GATA zinc finger domain containing 2A

• Vertebrate Orthologs
  10

• Human Ortholog
  GATAD2A, GATA zinc finger domain containing 2A
  Orthology source: HomoloGene, HGNC
• Synonyms
  p66alpha
• Links
  HGNC:29989

  NCBI Gene ID: 54815

  neXtProt AC: NX_Q86YP4

  UniProt: Q86YP4

  
  
• Chr Location
  19p13.11; chr19:19385833-19508932 (+)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 9766
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: GATAD2A
• Gene Tree
  Gatad2a
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotypes from 1 allele in 1 genetic background
  1 images
  12 phenotype references
  

• All Mutations and Alleles
  273
• Chemically induced (other)
  1
• Gene trapped
  269
• Targeted
  3
• Genomic Mutations
  1 involving Gatad2a
• Find Mice (IMSR)
  123 strains or lines available

Mice homozygous for a knock-out allele die around E9.5 displaying variable developmental defects, including malformed or unfused neural folds, failure of closure of anterior neuropore, missing or excessively large blood vessels in the yolk sac, abnormal embryo turning, and embryonic growth arrest.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  16
• GO References
  4

• External Resources
  FuncBase

Expression

• cDNA Data
  14

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  ZFIN gatad2ab

Interactions

• Gatad2a interacts with 289 markers (Mir7-1, Mir10a, Mir10b, ...) View All

Sequences &
Gene Models

• All Sequences
  90
• RefSeq
  30
• UniProt
  5
• CCDS
  CCDS22355.1, CCDS52567.1

• VEGA
  OTTMUSG00000062222 (Evidence)
• Ensembl
  ENSMUSG00000036180 (Evidence)
• NCBI Gene
  234366

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000062222	VEGA Gene Model | MGI Sequence Detail	89309	C57BL/6J
transcript	OTTMUST00000151807	VEGA | MGI Sequence Detail	3812	Not Applicable
polypeptide	OTTMUSP00000078703	VEGA | MGI Sequence Detail	630	Not Applicable

Polymorphisms

• SNPs within 2kb
  436 from dbSNP Build 142

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000007862 transcriptional repressor p66-alpha
  (term hierarchy)
• InterPro Domains
  IPR032346 Transcriptional repressor p66, coiled-coil MBD2-interaction domain
  IPR013088 Zinc finger, NHR/GATA-type

Molecular
Reagents

• All nucleic 15

  cDNA 14

  Primer pair 1

  
  

  Microarray probesets 7

Other
Accession IDs

MGI:1916181, MGI:2142860

References

• Summaries
  All 37

  Gene Ontology 4

  Phenotypes 12
• Earliest
  J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
• Latest
  J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582