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Gatad2a Gene Detail
Summary
  • Symbol
    Gatad2a
  • Name
    GATA zinc finger domain containing 2A
  • Synonyms
    1110066C11Rik, MGC:29315, MGC:36975
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384585
    NCBI Gene: 234366
Location & Maps
more
  • Sequence Map
    Chr8:69907069-69996379 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      89311 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.06 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GATAD2A, GATA zinc finger domain containing 2A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GATAD2A, GATA zinc finger domain containing 2A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    p66alpha
  • Links
    NCBI Gene ID: 54815
    neXtProt AC: NX_Q86YP4

  • Chr Location
    19p13.11; chr19:19385833-19508932 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    273
  • Chemically induced (other)
    1
  • Gene trapped
    269
  • Targeted
    3
  • Genomic Mutations
    1 involving Gatad2a
Mice homozygous for a knock-out allele die around E9.5 displaying variable developmental defects, including malformed or unfused neural folds, failure of closure of anterior neuropore, missing or excessively large blood vessels in the yolk sac, abnormal embryo turning, and embryonic growth arrest.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036180 Ensembl Gene Model | MGI Sequence Detail 89311 C57BL/6J ±  kb
transcript ENSMUST00000065169 Ensembl | MGI Sequence Detail 5208 Not Applicable  
polypeptide ENSMUSP00000070229 Ensembl | MGI Sequence Detail 630 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    436 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007862 transcriptional repressor p66-alpha
  • InterPro Domains
    IPR032346 Transcriptional repressor p66, coiled-coil MBD2-interaction domain
Molecular
Reagents
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  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1916181, MGI:2142860
References
more
  • Summaries
    All 34
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory