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Gatad2a Gene Detail
Summary
  • Symbol
    Gatad2a
  • Name
    GATA zinc finger domain containing 2A
  • Synonyms
    1110066C11Rik, MGC:29315, MGC:36975
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384585
    NCBI Gene: 234366
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:69907076-69996384 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.06 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    436 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384585
 protein coding gene Chr8:69907069-69996402 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033684
 protein coding gene Chr8:70135962-70231858 (-)
A/J MGP_AJ_G0033667
 protein coding gene Chr8:67288543-67378621 (-)
AKR/J MGP_AKRJ_G0033592
 protein coding gene Chr8:69194783-69285751 (-)
BALB/cJ MGP_BALBcJ_G0033663
 protein coding gene Chr8:67514559-67603288 (-)
C3H/HeJ MGP_C3HHeJ_G0033373
 protein coding gene Chr8:69855811-69944163 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034180
 protein coding gene Chr8:72804135-72898155 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031124
 protein coding gene Chr8:62112900-62201273 (-)
CAST/EiJ MGP_CASTEiJ_G0032698
 protein coding gene Chr8:69320642-69416573 (-)
CBA/J MGP_CBAJ_G0033351
 protein coding gene Chr8:75441837-75539962 (-)
DBA/2J MGP_DBA2J_G0033505
 protein coding gene Chr8:67014792-67103696 (-)
FVB/NJ MGP_FVBNJ_G0033446
 protein coding gene Chr8:66111448-66201787 (-)
LP/J MGP_LPJ_G0033592
 protein coding gene Chr8:70186273-70276168 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033490
 protein coding gene Chr8:78099291-78199662 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034198
 protein coding gene Chr8:69377456-69471395 (-)
PWK/PhJ MGP_PWKPhJ_G0032406
 protein coding gene Chr8:66299565-66390569 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032242
 protein coding gene Chr8:68355765-68447599 (-)
WSB/EiJ MGP_WSBEiJ_G0032813
 protein coding gene Chr8:69746639-69835511 (-)



Homology
more
  • Human Ortholog
    GATAD2A, GATA zinc finger domain containing 2A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GATAD2A, GATA zinc finger domain containing 2A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p66alpha
  • Links
    NCBI Gene ID: 54815
    neXtProt AC: NX_Q86YP4
    UniProt: Q86YP4

  • Chr Location
    19p13.11; chr19:19385833-19508932 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die around E9.5 displaying variable developmental defects, including malformed or unfused neural folds, failure of closure of anterior neuropore, missing or excessively large blood vessels in the yolk sac, abnormal embryo turning, and embryonic growth arrest.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    640
  • Tissues
    7
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036180 Ensembl Gene Model | MGI Sequence Detail 89309 C57BL/6J ±  kb
    transcript ENSMUST00000065169 Ensembl | MGI Sequence Detail 3812 Not Applicable  
    polypeptide ENSMUSP00000070229 Ensembl | MGI Sequence Detail 630 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000007862 transcriptional repressor p66-alpha
      (term hierarchy)
    • InterPro Domains
      IPR040386 Transcriptional repressor p66
      IPR032346 Transcriptional repressor p66, coiled-coil MBD2-interaction domain
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916181, MGI:2142860
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:271375 Mor N, et al., Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency. Cell Stem Cell. 2018 Sep 6;23(3):412-425.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    02/23/2021
    MGI 6.16     		The Jackson Laboratory