Zfp280d MGI Mouse Gene Detail - MGI:2384583

Symbol

Zfp280d
Name

zinc finger protein 280D
Synonyms

MGC:36902, Suhw4

Feature Type

protein coding gene
IDs

MGI:2384583
NCBI Gene: 235469
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr9:72182142-72271059 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 40.08 cM
Mapping Data

3 experiments

SNPs within 2kb

3341 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2384583	protein coding gene	Chr9:72181900-72271061 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035013	protein coding gene	Chr9:72425874-72517401 (+)
A/J	MGP_AJ_G0034994	protein coding gene	Chr9:69905868-69996731 (+)
AKR/J	MGP_AKRJ_G0034923	protein coding gene	Chr9:71570965-71661741 (+)
BALB/cJ	MGP_BALBcJ_G0034986	protein coding gene	Chr9:69608294-69702486 (+)
C3H/HeJ	MGP_C3HHeJ_G0034695	protein coding gene	Chr9:72070141-72165155 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035505	protein coding gene	Chr9:74327476-74418100 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032416	protein coding gene	Chr9:69396003-69484863 (+)
CAST/EiJ	MGP_CASTEiJ_G0034017	protein coding gene	Chr9:72375405-72472558 (+)
CBA/J	MGP_CBAJ_G0034668	protein coding gene	Chr9:76908029-77017033 (+)
DBA/2J	MGP_DBA2J_G0034827	protein coding gene	Chr9:69621452-69712951 (+)
FVB/NJ	MGP_FVBNJ_G0034769	protein coding gene	Chr9:68937915-69027556 (+)
LP/J	MGP_LPJ_G0034908	protein coding gene	Chr9:72628264-72720895 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034810	protein coding gene	Chr9:77982365-78090385 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035527	protein coding gene	Chr9:71708524-71803501 (+)
PWK/PhJ	MGP_PWKPhJ_G0033721	protein coding gene	Chr9:69877314-69968929 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033554	protein coding gene	Chr9:72015114-72108254 (+)
WSB/EiJ	MGP_WSBEiJ_G0034129	protein coding gene	Chr9:71632942-71737430 (+)

Human Ortholog

ZNF280D, zinc finger protein 280D

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF280D, zinc finger protein 280D
Synonyms

SUHW4, ZNF634
Links

HGNC:25953

NCBI Gene ID: 54816

UniProt: Q6N043
Chr Location

15q21.3; chr15:56630176-56734086 (-) GRCh38

MGI Vertebrate Homology

Zfp280d stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZNF280D
Gene Tree

Zfp280d

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

81
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

76
Targeted

2
Genomic Mutations

1 involving Zfp280d
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

117 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

18
cDNA Data

100
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN znf280d

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All Sequences

102
RefSeq

19
UniProt

13
CCDS

CCDS40683.1, CCDS81035.1

Ensembl

ENSMUSG00000038535 (Evidence)
NCBI Gene

235469

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038535	Ensembl Gene Model \| MGI Sequence Detail	88918	C57BL/6J	± kb
transcript	ENSMUST00000098576	Ensembl \| MGI Sequence Detail	4387	Not Applicable
polypeptide	ENSMUSP00000096175	Ensembl \| MGI Sequence Detail	974	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000017803 zinc finger protein 280D

(term hierarchy)
InterPro Domains

IPR025243 Domain of unknown function DUF4195

IPR050527 Snail/Krueppel C2H2-type Zinc-finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

Q68FE8 2 sites, 1 N-linked glycan (1 site)

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All nucleic 102

cDNA 101

Primer pair 1

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 13
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zfp280d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85968	Chr9:72182155-72182168 (+)	20 bp
Tssr85969	Chr9:72182183-72182195 (+)	47 bp
Tssr85970	Chr9:72182223-72182232 (+)	86 bp
Tssr85971	Chr9:72182248-72182295 (+)	130 bp
Tssr85972	Chr9:72182301-72182308 (+)	163 bp
Tssr85973	Chr9:72182769-72182781 (+)	633 bp
Tssr85974	Chr9:72186440-72186445 (+)	4,301 bp
Tssr85976	Chr9:72201594-72201597 (+)	19,454 bp
Tssr85977	Chr9:72213152-72213158 (+)	31,013 bp
Tssr85978	Chr9:72213951-72213961 (+)	31,814 bp
Tssr85979	Chr9:72259648-72259652 (+)	77,508 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24