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Ces4a Gene Detail
Summary
  • Symbol
    Ces4a
  • Name
    carboxylesterase 4A
  • Synonyms
    Ces8, MGC:31116
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384581
    NCBI Gene: 234677
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:105131800-105150109 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384581
protein coding gene Chr8:105131800-105150109 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034027
protein coding gene Chr8:107380274-107404042 (+)
A/J MGP_AJ_G0034008
protein coding gene Chr8:103103731-103126305 (+)
AKR/J MGP_AKRJ_G0033934
protein coding gene Chr8:106083101-106102777 (+)
BALB/cJ MGP_BALBcJ_G0034001
protein coding gene Chr8:103270517-103300121 (+)
C3H/HeJ MGP_C3HHeJ_G0033713
protein coding gene Chr8:106830297-106849842 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034521
protein coding gene Chr8:111314800-111340952 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031463
protein coding gene Chr8:96255138-96283183 (+)
CAST/EiJ MGP_CASTEiJ_G0033039
protein coding gene Chr8:106320358-106338584 (+)
CBA/J MGP_CBAJ_G0033686
protein coding gene Chr8:114905835-114939898 (+)
DBA/2J MGP_DBA2J_G0033841
protein coding gene Chr8:102452845-102471984 (+)
FVB/NJ MGP_FVBNJ_G0033787
protein coding gene Chr8:101376983-101395471 (+)
LP/J MGP_LPJ_G0033932
protein coding gene Chr8:107531268-107615904 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033830
protein coding gene Chr8:118140282-118163191 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034539
protein coding gene Chr8:106056665-106077799 (+)
PWK/PhJ MGP_PWKPhJ_G0032740
protein coding gene Chr8:101835866-101854985 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032581
protein coding gene Chr8:104735550-104753224 (+)
WSB/EiJ MGP_WSBEiJ_G0033155
protein coding gene Chr8:106703638-106724782 (+)



Homology
more
  • Human Ortholog
    CES4A, carboxylesterase 4A
  • Vertebrate Orthologs
    5
  • Human Ortholog
    CES4A, carboxylesterase 4A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CES6, CES8
  • Links
    NCBI Gene ID: 283848
    neXtProt AC: NX_Q5XG92
    UniProt: Q5XG92

  • Chr Location
    16q22.1; chr16:66988589-67009758 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 234677 NCBI Gene Model | MGI Sequence Detail 18310 C57BL/6J ±  kb
    transcript NM_146213 RefSeq | MGI Sequence Detail 2433 C57BL/6  
    polypeptide Q8R0W5 UniProt | EBI | MGI Sequence Detail 563 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 24
      Gene Ontology 2
      Phenotypes 6
    • Earliest
      J:164863 Holmes RS, et al., Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Mamm Genome. 2010 Oct;21(9-10):427-41
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    02/16/2021
    MGI 6.16
    The Jackson Laboratory