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Tmem45b Gene Detail
Summary
  • Symbol
    Tmem45b
  • Name
    transmembrane protein 45b
  • Synonyms
    MGC:25912, MGC:37581
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384574
    NCBI Gene: 235135
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:31337492-31375758 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 16.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384574
 protein coding gene Chr9:31336445-31375758 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034520
 protein coding gene Chr9:29116384-29153917 (-)
A/J MGP_AJ_G0034498
 protein coding gene Chr9:28395697-28435505 (-)
AKR/J MGP_AKRJ_G0034424
 protein coding gene Chr9:28970916-29012323 (-)
BALB/cJ MGP_BALBcJ_G0034489
 protein coding gene Chr9:28262944-28301621 (-)
C3H/HeJ MGP_C3HHeJ_G0034201
 protein coding gene Chr9:29337288-29376870 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035010
 protein coding gene Chr9:30114095-30151582 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031940
 protein coding gene Chr9:27220278-27260516 (-)
CAST/EiJ MGP_CASTEiJ_G0033524
 protein coding gene Chr9:29193474-29235643 (-)
CBA/J MGP_CBAJ_G0034175
 protein coding gene Chr9:31097505-31142208 (-)
DBA/2J MGP_DBA2J_G0034332
 protein coding gene Chr9:28402742-28443728 (-)
FVB/NJ MGP_FVBNJ_G0034275
 protein coding gene Chr9:27805746-27843136 (-)
LP/J MGP_LPJ_G0034418
 protein coding gene Chr9:29330741-29369528 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034319
 protein coding gene Chr9:32736598-32778199 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035030
 protein coding gene Chr9:28974996-29014020 (-)
PWK/PhJ MGP_PWKPhJ_G0033229
 protein coding gene Chr9:28340168-28380961 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033064
 protein coding gene Chr9:29079731-29116451 (-)
WSB/EiJ MGP_WSBEiJ_G0033639
 protein coding gene Chr9:28722009-28762141 (-)



Homology
more
  • Human Ortholog
    TMEM45B, transmembrane protein 45B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM45B, transmembrane protein 45B
  • Links
    NCBI Gene ID: 120224
    neXtProt AC: NX_Q96B21
    UniProt: Q96B21

  • Chr Location
    11q24.3; chr11:129815848-129860003 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced long-lasting mechanical pain hypersensitivity in a CFA-induced inflammatory pain model or following surgical tissue incision.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    819
  • Tissues
    16
  • cDNA Data
    24
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041737 Ensembl Gene Model | MGI Sequence Detail 38267 C57BL/6J ±  kb
transcript ENSMUST00000048050 Ensembl | MGI Sequence Detail 1799 Not Applicable  
polypeptide ENSMUSP00000042313 Ensembl | MGI Sequence Detail 278 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:331496 Tanioku T, et al., Tmem45b is essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2121989119
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory