About   Help   FAQ
Cplx3
Gene Detail
Symbol

Name
ID
Cplx3
complexin 3
MGI:2384571
Synonyms
CpxIII, Lman1l, MGC:21420, MGC:38804
Feature Type
protein coding gene
Genetic Map
Chromosome 9
31.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:57600019-57606281 bp, - strand
From Ensembl annotation of GRCm38

  6263 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77368  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: CPLX3
Gene Tree: Cplx3

Human
homologs
CPLX3, complexin 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 594855
neXtProt AC: NX_Q8WVH0

Human Synonyms: CPXIII, CPX-III, Nbla11589

Human Chr (Location): 15q24.1; chr15:74826610-74831795 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele are fertile, viable and exhibit normal synaptic transmission.
 
Interactions
Cplx3 interacts with 239 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process exocytosis, insulin secretion, ...
Component cell, cell junction, ...
Function neurotransmitter transporter activity, SNARE binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(16)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cplx3    NEW 
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000039714 (Evidence)
Entrez Gene 235415 (Evidence)
UniGene 35242
DFCI TC1580968
DoTS DT.97368195
NIA Mouse Gene Index U030924
Consensus CDS Project CCDS23226.1
International Mouse Phenotyping Consortium Status Cplx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039714 Ensembl Gene Model | MGI Sequence Detail 6263 C57BL/6J ±  kb
transcript ENSMUST00000045068 Ensembl | MGI Sequence Detail 2832 Not Applicable 
polypeptide ENSMUSP00000046748 Ensembl | MGI Sequence Detail 158 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008849 Synaphin
Protein Ontology PR:000005811 complexin-3
References
(Earliest) J:99464 Reim K, et al., Structurally and functionally unique complexins at retinal ribbon synapses. J Cell Biol. 2005 May 23;169(4):669-80
(Latest) J:218225 Imig C, et al., The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones. Neuron. 2014 Oct 22;84(2):416-31
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory