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Cplx3
Gene Detail
 Symbol
Name
ID
Cplx3
complexin 3
MGI:2384571
Synonyms CpxIII, Lman1l, MGC:21420, MGC:38804
Feature Type protein coding gene
Genetic Map
Chromosome 9
31.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:57600019-57606281 bp, - strand
From Ensembl annotation of GRCm38

  6263 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77368  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Gene Tree: Cplx3

Human
homologs
Human Homolog CPLX3, complexin 3
NCBI Gene ID 594855
neXtProt AC  NX_Q8WVH0
Human Synonyms  CPXIII, CPX-III
Human Chr (Location)  15q24.1; chr15:74826610-74831795 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele are fertile, viable and exhibit normal synaptic transmission.
 
Interactions
Cplx3 interacts with 239 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process exocytosis, insulin secretion, ...
Component cell, cell junction, ...
Function neurotransmitter transporter activity, SNARE binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000039714 (Evidence)
Entrez Gene235415 (Evidence)
UniGene35242
DFCITC1580968
DoTSDT.97368195
NIA Mouse Gene IndexU030924
Consensus CDS ProjectCCDS23226.1
International Mouse Knockout Project StatusCplx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039714 Ensembl Gene Model | MGI Sequence Detail 6263 C57BL/6J ±  kb
transcript ENSMUST00000045068 Ensembl | MGI Sequence Detail 2832 Not Applicable 
polypeptide ENSMUSP00000046748 Ensembl | MGI Sequence Detail 158 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008849 Synaphin
Protein Ontology PR:000005811 complexin-3
References (Earliest) J:99464 Reim K, et al., Structurally and functionally unique complexins at retinal ribbon synapses. J Cell Biol. 2005 May 23;169(4):669-80
(Latest) J:207661 Landgraf I, et al., The absence of Complexin 3 and Complexin 4 differentially impacts the ON and OFF pathways in mouse retina. Eur J Neurosci. 2012 Aug;36(4):2470-81
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/08/2014
MGI 5.18
The Jackson Laboratory