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Kank2 Gene Detail
Summary
  • Symbol
    Kank2
  • Name
    KN motif and ankyrin repeat domains 2
  • Synonyms
    Ankrd25, MGC:12143, MGC:7734
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384568
    NCBI Gene: 235041
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21678069-21709842 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    983 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384568
 protein coding gene Chr9:21678069-21710040 (-)
129S1/SvImJ ENSMUSG00200047131
 protein coding gene Chr9:18632326-18664294 (-)
A/J ENSMUSG00195037541
 protein coding gene Chr9:18468942-18500911 (-)
AKR/J ENSMUSG00220028807
 protein coding gene Chr9:18471375-18503344 (-)
BALB/cJ ENSMUSG00180035739
 protein coding gene Chr9:18603243-18635210 (-)
C3H/HeJ ENSMUSG00175041846
 protein coding gene Chr9:18565788-18597749 (-)
C57BL/6NJ ENSMUSG00215036519
 protein coding gene Chr9:18563077-18595047 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031882
 protein coding gene Chr9:17776937-17805343 (-)
CAST/EiJ ENSTCUG00005032004
 protein coding gene Chr9:18614370-18646306 (-)
CBA/J ENSMUSG00210032947
 protein coding gene Chr9:18546712-18578675 (-)
DBA/2J ENSMUSG00185026062
 protein coding gene Chr9:18662011-18693974 (-)
FVB/NJ ENSMUSG00205038181
 protein coding gene Chr9:18890269-18922733 (-)
JF1/MsJ ENSUMUG00000040555
 protein coding gene Chr9:18768543-18800201 (-)
LP/J ENSMUSG00230040300
 protein coding gene Chr9:19049498-19081955 (-)
NOD/ShiLtJ ENSMUSG00190027165
 protein coding gene Chr9:18583256-18615719 (-)
NZO/HlLtJ ENSMUSG00225048568
 protein coding gene Chr9:19003994-19035957 (-)
PWK/PhJ ENSLUMG00010040824
 protein coding gene Chr9:18660434-18691082 (-)
SPRET/EiJ ENSMSPG00010021973
 protein coding gene Chr9:18892853-18922012 (-)
WSB/EiJ ENSIUOG00005043322
 protein coding gene Chr9:18131702-18164390 (-)



Homology
more
  • Human Ortholog
    KANK2, KN motif and ankyrin repeat domains 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KANK2, KN motif and ankyrin repeat domains 2
  • Synonyms
    ANKRD25, MXRA3, NPHS16, PPKWH, SIP
  • Links
    NCBI Gene ID: 25959
    UniProt: Q63ZY3

  • Chr Location
    19p13.2; chr19:11164267-11197945 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KANK2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    8
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    609
  • Tissues
    10
  • cDNA Data
    29
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 235041 NCBI Gene Model | MGI Sequence Detail 31774 C57BL/6J ±  kb
transcript NM_145611 RefSeq | MGI Sequence Detail 4853 C57BL/6  
polypeptide Q8BX02 UniProt | EBI | MGI Sequence Detail 843 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000032283 KN motif and ankyrin repeat domain-containing protein 2
    (term hierarchy)
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR036770 Ankyrin repeat-containing domain superfamily
    IPR021939 Kank N-terminal motif
    IPR047184 KN motif and ankyrin repeat domain-containing protein 1-4
  • GlyGen
    Q8BX02 2 sites, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 30
    cDNA 29
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2143085
References
more
  • Summaries
    All 49
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory