About   Help   FAQ
Aars
Gene Detail
Symbol

Name
ID
Aars
alanyl-tRNA synthetase
MGI:2384560
Synonyms
MGC:37368
Feature Type
protein coding gene
Genetic Map
Chromosome 8
57.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:111033144-111057664 bp, + strand
From VEGA annotation of GRCm38

  24521 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1213  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AARS
Protein SuperFamily: alanyl-tRNA ligase
Gene Tree: Aars

Human
homologs
AARS, alanyl-tRNA synthetase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 16
neXtProt AC: NX_P49588

Human Synonyms: CMT2N, EIEE29

Human Chr (Location): 16q22; chr16:70252295-70289550 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human AARS

Mutations,
alleles, and
phenotypes
All mutations/alleles(66) : Gene trapped(62) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Phenotype Images(2)
Interactions
Aars interacts with 244 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process alanyl-tRNA aminoacylation, cellular response to unfolded protein, ...
Component cytoplasm, extracellular exosome, ...
Function alanine-tRNA ligase activity, amino acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA AARS ; Xenbase aars ; ZFIN aars    NEW 
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000031898 (Evidence)
Ensembl Gene Model ENSMUSG00000031960 (Evidence)
Entrez Gene 234734 (Evidence)
DFCI TC1573789
EC 6.1.1.7
Consensus CDS Project CCDS40478.1
International Mouse Phenotyping Consortium Status Aars
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031898 VEGA Gene Model | MGI Sequence Detail 24521 C57BL/6J ±  kb
transcript OTTMUST00000079077 VEGA | MGI Sequence Detail 5750 Not Applicable 
polypeptide OTTMUSP00000042139 VEGA | MGI Sequence Detail 968 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(8) UniProt(6)
Polymorphisms
SNPs within 2kb(183 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002318 Alanine-tRNA ligase, class IIc
InterPro IPR018162 Alanine-tRNA ligase, class IIc, anti-codon-binding domain
InterPro IPR023033 Alanine-tRNA ligase, eukaryota/bacteria
InterPro IPR018165 Alanyl-tRNA synthetase, class IIc, core domain
InterPro IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal
InterPro IPR003156 Phosphoesterase, DHHA1
InterPro IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain
InterPro IPR012947 Threonyl/alanyl tRNA synthetase, SAD
InterPro IPR009000 Translation elongation/initiation factor/Ribosomal, beta-barrel
Protein Ontology PR:000003529 alanine--tRNA ligase, cytoplasmic
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:216802 Liu Y, et al., Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17570-5
All references(42)
Other
accession IDs
MGI:1890634, MGI:2142499, MGI:2142843

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory