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Aars
Gene Detail
 Symbol
Name
ID
Aars
alanyl-tRNA synthetase
MGI:2384560
Synonyms MGC:37368
Feature Type protein coding gene
Genetic Map
Chromosome 8
57.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:111033144-111057664 bp, + strand
From VEGA annotation of GRCm38

  24521 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1213  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: alanyl-tRNA ligase
Gene Tree: Aars

Human
homologs
Human Homolog AARS, alanyl-tRNA synthetase
NCBI Gene ID 16
neXtProt AC  NX_P49588
Human Synonyms  CMT2N
Human Chr (Location)  16q22; chr16:70252394-70289555 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human AARS
Mutations,
alleles, and
phenotypes
All mutations/alleles(64) : Gene trapped(62) Spontaneous(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous point mutation have a rough, unkempt and sticky fur, display follicular dystrophy and patchy hair loss, develop tremors that progress to ataxia, and exhibit extensive loss of cerebellar Purkinje cells by 6 weeks of age.
 
Phenotype Images(2)
Interactions
Aars interacts with 244 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process alanyl-tRNA aminoacylation, cellular response to unfolded protein, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function alanine-tRNA ligase activity, amino acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (9)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031898 (Evidence)
Ensembl Gene ModelENSMUSG00000031960 (Evidence)
Entrez Gene234734 (Evidence)
DFCITC1573789
EC6.1.1.7
Consensus CDS ProjectCCDS40478.1
International Mouse Knockout Project StatusAars
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031898 VEGA Gene Model | MGI Sequence Detail 24521 C57BL/6J ±  kb
transcript OTTMUST00000079077 VEGA | MGI Sequence Detail 5750 Not Applicable 
polypeptide OTTMUSP00000042139 VEGA | MGI Sequence Detail 968 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(10) UniProt(6)
Polymorphisms SNPs within 2kb(183 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002318 Alanine-tRNA ligase, class IIc
InterPro IPR018162 Alanine-tRNA ligase, class IIc, anti-codon-binding domain
InterPro IPR023033 Alanine-tRNA ligase, eukaryota/bacteria
InterPro IPR018165 Alanyl-tRNA synthetase, class IIc, core domain
InterPro IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal
InterPro IPR003156 Phosphoesterase, DHHA1
InterPro IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain
InterPro IPR012947 Threonyl/alanyl tRNA synthetase, SAD
InterPro IPR009000 Translation elongation/initiation factor/Ribosomal, beta-barrel
Protein Ontology PR:000003529 alanine--tRNA ligase, cytoplasmic
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:193640 Lo JC, et al., RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet. 2012;8(10):e1002969
All references(43)
Other
accession IDs
MGI:1890634, MGI:2142499, MGI:2142843

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory