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Rgs9bp Gene Detail
Summary
  • Symbol
    Rgs9bp
  • Name
    regulator of G-protein signalling 9 binding protein
  • Synonyms
    R9AP, Rgs9-1bp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384418
    NCBI Gene: 243923
Location & Maps
more
  • Sequence Map
    Chr7:35578993-35585582 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6590 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 21.37 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RGS9BP, regulator of G-protein signaling 9 binding protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RGS9BP, regulator of G-protein signaling 9 binding protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PERRS, R9AP, RGS9
  • Links
    NCBI Gene ID: 388531
    neXtProt AC: NX_Q6ZS82

  • Chr Location
    19q13.11; chr19:32675407-32678300 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RGS9BP associations

Human Disease Mouse Models
       Prolonged Electroretinal Response Suppression; PERRS   OMIM: 608415
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Incidental Mutations
In spite of normal retinal morphology, rod light response is impaired in homozygous mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049777 VEGA Gene Model | MGI Sequence Detail 6590 C57BL/6J ±  kb
transcript OTTMUST00000126788 VEGA | MGI Sequence Detail 6590 Not Applicable  
polypeptide OTTMUSP00000068549 VEGA | MGI Sequence Detail 237 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    52 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013966 regulator of G-protein signaling 9-binding protein
  • InterPro Domains
    IPR026513 Regulator of G-protein signalling 9-binding protein
    IPR026512 RGS7BP/RGS9BP family
Molecular
Reagents
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  • All nucleic 27
    cDNA 27

    Microarray probesets 1
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:78055 Hu G, et al., R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9755-60
  • Latest
    J:200166 Tian M, et al., Light-induced translocation of RGS9-1 and Gbeta5L in mouse rod photoreceptors. PLoS One. 2013;8(3):e58832

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory