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Pdk3 Gene Detail
Summary
  • Symbol
    Pdk3
  • Name
    pyruvate dehydrogenase kinase, isoenzyme 3
  • Synonyms
    2610001M10Rik, MGC:6383
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384308
    NCBI Gene: 236900
  • Gene Overview
    MyGene.info: PDK3
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:93764616-93832095 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 41.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384308
protein coding gene ChrX:93764607-93832201 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035905
protein coding gene ChrX:90130704-90202924 (-)
A/J MGP_AJ_G0035891
protein coding gene ChrX:90233176-90304404 (-)
AKR/J MGP_AKRJ_G0035808
protein coding gene ChrX:92605561-92672662 (-)
BALB/cJ MGP_BALBcJ_G0035875
protein coding gene ChrX:88927728-88994860 (-)
C3H/HeJ MGP_C3HHeJ_G0035584
protein coding gene ChrX:90496569-90568788 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036404
protein coding gene ChrX:92884217-92959713 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033231
protein coding gene ChrX:88408188-88475768 (-)
CAST/EiJ MGP_CASTEiJ_G0034869
protein coding gene ChrX:75165045-75231211 (-)
CBA/J MGP_CBAJ_G0035558
protein coding gene ChrX:95576133-95648093 (-)
DBA/2J MGP_DBA2J_G0035714
protein coding gene ChrX:89483048-89550103 (-)
FVB/NJ MGP_FVBNJ_G0035653
protein coding gene ChrX:88876754-88944890 (-)
LP/J MGP_LPJ_G0035802
protein coding gene ChrX:90919835-90990155 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035687
protein coding gene ChrX:99865227-99937620 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036431
protein coding gene ChrX:89849207-89921427 (-)
PWK/PhJ MGP_PWKPhJ_G0034568
protein coding gene ChrX:72962216-73028747 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034398
protein coding gene ChrX:76024391-76091180 (-)
WSB/EiJ MGP_WSBEiJ_G0035010
protein coding gene ChrX:88652161-88722259 (-)



Homology
more
  • Human Ortholog
    PDK3, pyruvate dehydrogenase kinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDK3, pyruvate dehydrogenase kinase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMTX6, GS1-358P8.4
  • Links
    NCBI Gene ID: 5165
    neXtProt AC: NX_Q15120
    UniProt: Q15120

  • Chr Location
    Xp22.11; chrX:24465227-24550466 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PDK3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 236900 NCBI Gene Model | MGI Sequence Detail 67480 C57BL/6J ±  kb
transcript NM_145630 RefSeq | MGI Sequence Detail 2055 C57BL/6  
polypeptide Q922H2 UniProt | EBI | MGI Sequence Detail 415 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012506 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
  • EC
  • InterPro Domains
    IPR036784 Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
    IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
    IPR005467 Histidine kinase domain
    IPR003594 Histidine kinase/HSP90-like ATPase
    IPR036890 Histidine kinase/HSP90-like ATPase superfamily
    IPR039028 PDK/BCKDK protein kinase
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1914874, MGI:2147840
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:240758 Duteil D, et al., Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue. Cell Rep. 2016 Oct 18;17(4):1008-1021

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory