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Gga3 Gene Detail
Summary
  • Symbol
    Gga3
  • Name
    golgi associated, gamma adaptin ear containing, ARF binding protein 3
  • Synonyms
    C230037M19Rik, mKIAA0154
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384159
    NCBI Gene: 260302
  • Gene Overview
    MyGene.info: GGA3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115584255-115603925 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384159
protein coding gene Chr11:115584255-115604051 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019394
protein coding gene Chr11:119624617-119646929 (-)
A/J MGP_AJ_G0019363
protein coding gene Chr11:114401105-114420958 (-)
AKR/J MGP_AKRJ_G0019333
protein coding gene Chr11:117804064-117830326 (-)
BALB/cJ MGP_BALBcJ_G0019337
protein coding gene Chr11:114818215-114839010 (-)
C3H/HeJ MGP_C3HHeJ_G0019143
protein coding gene Chr11:118169428-118190277 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019787
protein coding gene Chr11:123276497-123297514 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017410
protein coding gene Chr11:111425879-111444957 (-)
CAST/EiJ MGP_CASTEiJ_G0018698
protein coding gene Chr11:119487717-119509068 (-)
CBA/J MGP_CBAJ_G0019115
protein coding gene Chr11:128151235-128174838 (-)
DBA/2J MGP_DBA2J_G0019226
protein coding gene Chr11:113831768-113852206 (-)
FVB/NJ MGP_FVBNJ_G0019218
protein coding gene Chr11:113320666-113341175 (-)
LP/J MGP_LPJ_G0019296
protein coding gene Chr11:120009779-120031166 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019251
protein coding gene Chr11:127293356-127313566 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019825
protein coding gene Chr11:118468060-118489362 (-)
PWK/PhJ MGP_PWKPhJ_G0018462
protein coding gene Chr11:115121934-115292063 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018255
protein coding gene Chr11:118216124-118238275 (-)
WSB/EiJ MGP_WSBEiJ_G0018750
protein coding gene Chr11:118432222-118453494 (-)



Homology
more
  • Human Ortholog
    GGA3, golgi associated, gamma adaptin ear containing, ARF binding protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GGA3, golgi associated, gamma adaptin ear containing, ARF binding protein 3
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 23163
    neXtProt AC: NX_Q9NZ52
    UniProt: Q9NZ52

  • Chr Location
    17q25.1; chr17:75225464-75262393 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele display decreased birth weight, slow postnatal weight gain, hypoglycemia, increased plasma levels of acid hydrolases, and partial neonatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 260302 NCBI Gene Model | MGI Sequence Detail 19671 C57BL/6J ±  kb
    transcript NM_173048 RefSeq | MGI Sequence Detail 3703 C57BL/6  
    polypeptide Q8BMI3 UniProt | EBI | MGI Sequence Detail 718 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      Genomic 2
      cDNA 74
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442936
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:264995 Kim W, et al., BACE1 elevation engendered by GGA3 deletion increases beta-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice. Mol Neurodegener. 2018 Feb 2;13(1):6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory