Fgd4
Gene Detail

Symbol Name ID

Fgd4 FYVE, RhoGEF and PH domain containing 4 MGI:2183747

Synonyms

9330209B17Rik, Frabin, Frabin-alpha, Frabin-beta, Frabin-gamma, ZFYVE6

Feature Type

protein coding gene

Genetic Map

Chromosome 16

10.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:16416917-16600549 bp, - strand From VEGA annotation of GRCm38   183633 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:26727  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: FYVE, RhoGEF and PH domain containing protein(1-4)
Gene Tree: Fgd4

Human homologs

Human Homolog		FGD4, FYVE, RhoGEF and PH domain containing 4
NCBI Gene ID		121512
neXtProt AC		NX_Q96M96
Human Synonyms		CMT4H, FRABP, ZFYVE6
Human Chr (Location)		12p11.21; chr12:32655041-32798984 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FGD4

Alleles and phenotypes

All alleles(79) : Targeted(7) Gene trapped(72)
Human Diseases Modeled Using Mouse Fgd4 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	activation of JUN kinase activity, lamellipodium assembly, ...
Component	actin cytoskeleton, cell projection, ...
Function	actin binding, actin filament binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (115)    Tissues (19)    Images (25)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	115

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(13)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000030883 (Evidence)
Ensembl Gene Model	ENSMUSG00000022788 (Evidence)
Entrez Gene	224014 (Evidence)
DFCI	TC1580379, TC1592927, TC1593173, TC1595663, TC1596473, TC1598049, TC1611971, TC1705276
DoTS	DT.110710690, DT.110710719, DT.40155285, DT.40164610, DT.524045, DT.60101205, DT.87031725, DT.91378972, DT.97352642
NIA Mouse Gene Index	U036828, U290456
Consensus CDS Project	CCDS27986.1, CCDS49773.1, CCDS49774.1
International Mouse Knockout Project Status	Fgd4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030883	VEGA Gene Model | MGI Sequence Detail	183633	C57BL/6J
transcript	OTTMUST00000076425	VEGA | MGI Sequence Detail	8342	Not Applicable
polypeptide	OTTMUSP00000040229	VEGA | MGI Sequence Detail	766	Not Applicable

All sequences(88) RefSeq(6) UniProt(5)

Polymorphisms

SNPs(210 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000219	Dbl homology (DH) domain
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR017455	Zinc finger, FYVE-related
InterPro	IPR000306	Zinc finger, FYVE-type
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000007476	FYVE, RhoGEF and PH domain-containing protein 4

References

(Earliest) J:78214 Obaishi H, et al., Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-terminal kinase. J Biol Chem. 1998 Jul 24;273(30):18697-700
(Latest) J:190437 Horn M, et al., Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells. Brain. 2012 Dec;135(Pt 12):3567-83
All references(41)

Other accession IDs

MGI:2442956