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Arfgap1 Gene Detail
Summary
  • Symbol
    Arfgap1
  • Name
    ADP-ribosylation factor GTPase activating protein 1
  • Synonyms
    ARF1 GAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183559
    NCBI Gene: 228998
  • Gene Overview
    MyGene.info: ARFGAP1
Location & Maps
more
  • Sequence Map
    Chr2:180967225-180982526 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15302 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 103.53 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ARFGAP1, ADP ribosylation factor GTPase activating protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARFGAP1, ADP ribosylation factor GTPase activating protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARF1GAP, HRIHFB2281
  • Links
    NCBI Gene ID: 55738
    neXtProt AC: NX_Q8N6T3

  • Chr Location
    20q13.33; chr20:63272785-63289793 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    14
  • Gene trapped
    10
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Arfgap1
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016397 VEGA Gene Model | MGI Sequence Detail 15302 C57BL/6J ±  kb
transcript OTTMUST00000039500 VEGA | MGI Sequence Detail 1393 Not Applicable  
polypeptide OTTMUSP00000065362 VEGA | MGI Sequence Detail 424 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    178 from dbSNP Build 142
Protein
Information
less
  • UniProt
    8 Sequences
  • InterPro Domains
    IPR001164 Arf GTPase activating protein
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138836
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:82964 Yang Y, et al., Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold. Hum Mol Genet. 2003 May 1;12(9):975-84
  • Latest
    J:216094 Schultz ML, et al., CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events. PLoS One. 2014;9(5):e96647

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory