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Arfgap1
Gene Detail
 Symbol
Name
ID
Arfgap1
ADP-ribosylation factor GTPase activating protein 1
MGI:2183559
Synonyms ARF1 GAP
Feature Type protein coding gene
Genetic Map
Chromosome 2
103.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:180967225-180982526 bp, + strand
From VEGA annotation of GRCm38

  15302 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5517  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ADP-ribosylation factor GTPase-activating protein, ArfGAP1 type
Gene Tree: Arfgap1

Human
homologs
Human Homolog ARFGAP1, ADP-ribosylation factor GTPase activating protein 1
NCBI Gene ID 55738
neXtProt AC  NX_Q8N6T3
Human Synonyms  ARF1GAP, HRIHFB2281
Human Chr (Location)  20q13.33; chr20:63272785-63289793 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(10) Spontaneous(1) Targeted(3)
Genomic Mutations involving Arfgap1 (1)
Incidental mutations (data from APF )
Interactions
Arfgap1 interacts with 160 markers (Mir16-1, Mir17, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process positive regulation of GTPase activity, protein transport, ...
Component cytoplasm, Golgi apparatus, ...
Function ARF GTPase activator activity, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (34)    Tissues (14)    Images (8)
Theiler Stages: 23
Assay TypeResults
RNA in situ 34
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016397 (Evidence)
Ensembl Gene ModelENSMUSG00000027575 (Evidence)
Entrez Gene228998 (Evidence)
DFCITC1574599, TC1586914, TC1599092, TC1601562, TC1621456, TC1642181
DoTSDT.101343928, DT.101737059, DT.101737060, DT.103565800, DT.532964, DT.91339964, DT.94388055, DT.99853814, DT.99860739
NIA Mouse Gene IndexU002972
Consensus CDS ProjectCCDS17190.1, CCDS50842.1, CCDS50843.1
International Mouse Knockout Project StatusArfgap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016397 VEGA Gene Model | MGI Sequence Detail 15302 C57BL/6J ±  kb
transcript OTTMUST00000039500 VEGA | MGI Sequence Detail 1393 Not Applicable 
polypeptide OTTMUSP00000065362 VEGA | MGI Sequence Detail 424 Not Applicable 

For the selected sequences
All sequences(124) RefSeq(26) UniProt(8)
Polymorphisms SNPs within 2kb(178 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001164 Arf GTPase activating protein
Protein Ontology PR:000004206 ADP-ribosylation factor GTPase-activating protein 1
References (Earliest) J:82964 Yang Y, et al., Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold. Hum Mol Genet. 2003 May 1;12(9):975-84
(Latest) J:183409 Stafa K, et al., GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. PLoS Genet. 2012 Feb;8(2):e1002526
All references(39)
Other
accession IDs
MGI:2138836

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory