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Cytip Gene Detail
Summary
  • Symbol
    Cytip
  • Name
    cytohesin 1 interacting protein
  • Synonyms
    A130053M09Rik, Cbp, Cybr, Pscdbp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183535
    NCBI Gene: 227929
  • Gene Overview
    MyGene.info: CYTIP
Location & Maps
more
  • Sequence Map
    Chr2:58129137-58195532 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      66396 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 33.05 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CYTIP, cytohesin 1 interacting protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYTIP, cytohesin 1 interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B3-1, CASP, CYBR, CYTHIP, HE, PSCDBP
  • Links
    NCBI Gene ID: 9595
    neXtProt AC: NX_O60759

  • Chr Location
    2q24.1; chr2:157414619-157444092 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3167
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CYTIP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Cytip
  • Incidental Mutations
Mice homozygous for a null allele display impaired trafficking and/or cell adhesion of immune system cells. Mice homozygous for a reporter allele show normal immune cell development and function; however, mutant hematopoietic stems cells have impaired repopulating activity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012676 VEGA Gene Model | MGI Sequence Detail 66396 C57BL/6J ±  kb
transcript OTTMUST00000030201 VEGA | MGI Sequence Detail 6110 Not Applicable  
polypeptide OTTMUSP00000013590 VEGA | MGI Sequence Detail 359 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    498 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 6
Other
Accession IDs
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MGI:2138967, MGI:2139510, MGI:2444809
References
more
  • Summaries
    All 35
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:187783 Heib V, et al., Cytip regulates dendritic-cell function in contact hypersensitivity. Eur J Immunol. 2012 Mar;42(3):589-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory