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Dlgap5 Gene Detail
Summary
  • Symbol
    Dlgap5
  • Name
    discs, large (Drosophila) homolog-associated protein 5
  • Synonyms
    C86398, Dlg7, Hurp, mKIAA0008
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183453
    NCBI Gene: 218977
Location & Maps
more
  • Sequence Map
    Chr14:47387779-47418407 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30629 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DLGAP5, discs large homolog associated protein 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DLGAP5, discs large homolog associated protein 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DLG7, HURP
  • Links
    NCBI Gene ID: 9787
    neXtProt AC: NX_Q15398

  • Chr Location
    14q22.3; chr14:55148116-55191678 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Targeted
    3
  • Genomic Mutations
    1 involving Dlgap5
  • Incidental Mutations
Mice homozygous for a null mutation display female infertility resulting from a defect in decidualization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042413 VEGA Gene Model | MGI Sequence Detail 30629 C57BL/6J ±  kb
transcript OTTMUST00000111820 VEGA | MGI Sequence Detail 2964 Not Applicable  
polypeptide OTTMUSP00000062686 VEGA | MGI Sequence Detail 808 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    380 from dbSNP Build 137
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR005026 SAPAP family
Molecular
Reagents
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  • All nucleic 100
    cDNA 99
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1353581, MGI:2145876
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:167991 Breuer M, et al., HURP permits MTOC sorting for robust meiotic spindle bipolarity, similar to extra centrosome clustering in cancer cells. J Cell Biol. 2010 Dec 27;191(7):1251-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory