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Uts2r Gene Detail
Summary
  • Symbol
    Uts2r
  • Name
    urotensin 2 receptor
  • Synonyms
    Gpr14, urotensin II receptor, UTR2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183450
    NCBI Gene: 217369
  • Gene Overview
    MyGene.info: UTS2R
Location & Maps
more
  • Sequence Map
    Chr11:121160271-121161973 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1703 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    UTS2R, urotensin 2 receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UTS2R, urotensin 2 receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GPR14, UR-2-R, UTR, UTR2
  • Links
    NCBI Gene ID: 2837
    neXtProt AC: NX_Q9UKP6

  • Chr Location
    17q25.3; chr17:82374277-82375586 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display a selective loss of urotensin-II contractile activity in isolated aortae.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004297 VEGA Gene Model | MGI Sequence Detail 1703 C57BL/6J ±  kb
transcript OTTMUST00000009740 VEGA | MGI Sequence Detail 1703 Not Applicable  
polypeptide OTTMUSP00000004687 VEGA | MGI Sequence Detail 385 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    35 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001561 urotensin-2 receptor
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR000670 Urotensin II receptor
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:103118 Behm DJ, et al., Deletion of the UT receptor gene results in the selective loss of urotensin-II contractile activity in aortae isolated from UT receptor knockout mice. Br J Pharmacol. 2003 May;139(2):464-72
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory