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Spata20 Gene Detail
Summary
  • Symbol
    Spata20
  • Name
    spermatogenesis associated 20
  • Synonyms
    Tisp78
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183449
    NCBI Gene: 217116
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:94478904-94485310 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 58.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183449
protein coding gene Chr11:94478904-94486179 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018957
protein coding gene Chr11:96574615-96581874 (-)
A/J MGP_AJ_G0018925
protein coding gene Chr11:92711659-92718921 (-)
AKR/J MGP_AKRJ_G0018895
protein coding gene Chr11:95596586-95603848 (-)
BALB/cJ MGP_BALBcJ_G0018898
protein coding gene Chr11:93162088-93169352 (-)
C3H/HeJ MGP_C3HHeJ_G0018712
protein coding gene Chr11:95679651-95686913 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019350
protein coding gene Chr11:99581926-99589246 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016981
protein coding gene Chr11:90206322-90213570 (-)
CAST/EiJ MGP_CASTEiJ_G0018267
protein coding gene Chr11:96396361-96403610 (-)
CBA/J MGP_CBAJ_G0018683
protein coding gene Chr11:103720832-103728116 (-)
DBA/2J MGP_DBA2J_G0018791
protein coding gene Chr11:92287415-92295196 (-)
FVB/NJ MGP_FVBNJ_G0018780
protein coding gene Chr11:91708873-91716144 (-)
LP/J MGP_LPJ_G0018861
protein coding gene Chr11:97119286-97126535 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018807
protein coding gene Chr11:103741781-103749036 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019390
protein coding gene Chr11:95823910-95831190 (-)
PWK/PhJ MGP_PWKPhJ_G0018037
protein coding gene Chr11:93220839-93228192 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017827
protein coding gene Chr11:95485413-95492711 (-)
WSB/EiJ MGP_WSBEiJ_G0018316
protein coding gene Chr11:95704484-95711734 (-)



Homology
more
  • Human Ortholog
    SPATA20, spermatogenesis associated 20
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPATA20, spermatogenesis associated 20
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-98, SSP411, Tisp78
  • Links
    NCBI Gene ID: 64847
    neXtProt AC: NX_Q8TB22
    UniProt: Q8TB22

  • Chr Location
    17q21.33; chr17:50547089-50555852 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Spata20 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility, small testes, severe oligoasthenoteratozoospermia, and abnormal manchette morphology during spermiogenesis resulting in impaired sperm head formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 217116 NCBI Gene Model | MGI Sequence Detail 6407 C57BL/6J ±  kb
transcript NM_144827 RefSeq | MGI Sequence Detail 2606 Not Specified  
polypeptide Q80YT5 UniProt | EBI | MGI Sequence Detail 790 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 2
References
more
  • Summaries
    All 26
    Diseases 2
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:262160 Liu M, et al., Disruption of Ssp411 causes impaired sperm head formation and male sterility in mice. Biochim Biophys Acta. 2018 Mar;1862(3):660-668

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory