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Diras1
Gene Detail
Symbol

Name
ID
Diras1
DIRAS family, GTP-binding RAS-like 1
MGI:2183442
Synonyms
Di-Ras1, GBTS1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:81019589-81025662 bp, - strand
From VEGA annotation of GRCm38

  6074 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:64823  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: DIRAS1
Protein SuperFamily: ras protein
Gene Tree: Diras1

Human
homologs
DIRAS1, DIRAS family, GTP-binding RAS-like 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 148252
neXtProt AC: NX_O95057

Human Synonyms: Di-Ras1, GBTS1, RIG

Human Chr (Location): 19p13.3; chr19:2714567-2721392 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Diras1 interacts with 207 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process signal transduction, small GTPase mediated signal transduction
Component membrane, plasma membrane
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (186)    Tissues (43)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 186
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase diras1 ; ZFIN diras1a    NEW 
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000030296 (Evidence)
Ensembl Gene Model ENSMUSG00000043670 (Evidence)
Entrez Gene 208666 (Evidence)
DFCI TC1580825
DoTS DT.99675872
NIA Mouse Gene Index U032030
Consensus CDS Project CCDS24040.1
International Mouse Phenotyping Consortium Status Diras1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030296 VEGA Gene Model | MGI Sequence Detail 6074 C57BL/6J ±  kb
transcript OTTMUST00000075002 VEGA | MGI Sequence Detail 2953 Not Applicable 
polypeptide OTTMUSP00000039245 VEGA | MGI Sequence Detail 198 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000006486 GTP-binding protein Di-Ras1
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory