Med9 Gene Detail

Summary

• Symbol
  Med9
• Name
  mediator complex subunit 9
• Synonyms
  Med25, MED25, MGC:30366

• Feature Type
  protein coding gene
• IDs
  MGI:2183151
  NCBI Gene: 192191
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr11:59839032-59853031 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 37.81 cM
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  94 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2183151	protein coding gene	Chr11:59839032-59854132 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018409	protein coding gene	Chr11:59805266-59819260 (+)
A/J	MGP_AJ_G0018378	protein coding gene	Chr11:57533288-57545777 (+)
AKR/J	MGP_AKRJ_G0018348	protein coding gene	Chr11:59449361-59463496 (+)
BALB/cJ	MGP_BALBcJ_G0018349	protein coding gene	Chr11:57875424-57889403 (+)
C3H/HeJ	MGP_C3HHeJ_G0018162	protein coding gene	Chr11:59328351-59340840 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018801	protein coding gene	Chr11:61704627-61720105 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016447	protein coding gene	Chr11:54776614-54790866 (+)
CAST/EiJ	MGP_CASTEiJ_G0017719	protein coding gene	Chr11:59461149-59473412 (+)
CBA/J	MGP_CBAJ_G0018136	protein coding gene	Chr11:64406302-64418791 (+)
DBA/2J	MGP_DBA2J_G0018245	protein coding gene	Chr11:57189786-57203976 (+)
FVB/NJ	MGP_FVBNJ_G0018236	protein coding gene	Chr11:56849811-56863815 (+)
LP/J	MGP_LPJ_G0018318	protein coding gene	Chr11:60409024-60423025 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018260	protein coding gene	Chr11:65484402-65498436 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018842	protein coding gene	Chr11:59483160-59496926 (+)
PWK/PhJ	MGP_PWKPhJ_G0017490	protein coding gene	Chr11:57790853-57803370 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017282	protein coding gene	Chr11:59274666-59291130 (+)
WSB/EiJ	MGP_WSBEiJ_G0017770	protein coding gene	Chr11:59154445-59168444 (+)

Homology

• Human Ortholog
  MED9, mediator complex subunit 9

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  MED9, mediator complex subunit 9
  
• Synonyms
  MED25
• Links
  HGNC:25487

  NCBI Gene ID: 55090

  neXtProt AC: NX_Q9NWA0

  UniProt: Q9NWA0

  
  
• Chr Location
  17p11.2; chr17:17476994-17493221 (+)  GRCh38

---

• MGI Vertebrate Homology
  Med9 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: MED9
• Gene Tree
  Med9
  

Human Diseases

• References
  3 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  19 phenotype references
  

• All Mutations and Alleles
  15
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Gene trapped
  7
• Targeted
  6
• Genomic Mutations
  4 involving Med9
• Find Mice (IMSR)
  11 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  11
• GO References
  6

Expression

• Assay Results
  706
• cDNA Data
  3

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase med9

Sequences &
Gene Models

• All Sequences
  31
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS24780.1

• Ensembl
  ENSMUSG00000061650 (Evidence)
• NCBI Gene
  192191

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000061650	Ensembl Gene Model | MGI Sequence Detail	14000	C57BL/6J
transcript	ENSMUST00000081980	Ensembl | MGI Sequence Detail	1920	Not Applicable
polypeptide	ENSMUSP00000080641	Ensembl | MGI Sequence Detail	142	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000010308 mediator of RNA polymerase II transcription subunit 9
  (term hierarchy)
• PDB
  6W1S
• InterPro Domains
  IPR037212 Mediator complex, subunit Med7/Med21-like
  IPR011425 Mediator of RNA polymerase II transcription subunit 9
  IPR039242 Mediator of RNA polymerase II transcription subunit 9, metazoan

Molecular
Reagents

• All nucleic 4

  Genomic 1

  cDNA 3

  
  

  Microarray probesets 3

References

• Summaries
  All 42

  Diseases 3

  Gene Ontology 6

  Phenotypes 19
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:185284 Lacaria M, et al., Enriched rearing improves behavioral responses of an animal model for CNV-based autistic-like traits. Hum Mol Genet. 2012 Jul 15;21(14):3083-96

TSS for Med9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101871	Chr11:59839035-59839087 (+)	29 bp