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Sardh Gene Detail
Summary
  • Symbol
    Sardh
  • Name
    sarcosine dehydrogenase
  • Synonyms
    MGC:6279
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183102
    NCBI Gene: 192166
  • Gene Overview
    MyGene.info: SARDH
Location & Maps
more
  • Sequence Map
    Chr2:27188393-27248337 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59945 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 19.31 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SARDH, sarcosine dehydrogenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SARDH, sarcosine dehydrogenase
    Orthology source: HomoloGene
  • Synonyms
    BPR-2, DMGDHL1, SAR, SARD, SDH
  • Links
    NCBI Gene ID: 1757
    neXtProt AC: NX_Q9UL12

  • Chr Location
    9q33-q34; chr9:133661740-133739955 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 5149
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SARDH
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human SARDH associations

Human Disease Mouse Models
       Sarcosinemia; SARCOS   OMIM: 268900
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012037 VEGA Gene Model | MGI Sequence Detail 59945 C57BL/6J ±  kb
transcript OTTMUST00000028625 VEGA | MGI Sequence Detail 4521 Not Applicable  
polypeptide OTTMUSP00000012947 VEGA | MGI Sequence Detail 919 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    468 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000014456 sarcosine dehydrogenase, mitochondrial
  • EC
  • InterPro Domains
    IPR006076 FAD dependent oxidoreductase
    IPR032503 FAD dependent oxidoreductase, central domain
    IPR023753 FAD/NAD(P)-binding domain
    IPR013977 Glycine cleavage T-protein, C-terminal barrel domain
    IPR006222 Glycine cleavage T-protein-like, N-terminal
    IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal domain
    IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1
Molecular
Reagents
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  • All nucleic 153
    cDNA 152
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 25
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:86816 Mootha VK, et al., Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell. 2003 Nov 26;115(5):629-40
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory