Sardh
Gene Detail

Symbol Name ID

Sardh sarcosine dehydrogenase MGI:2183102

Synonyms

MGC:6279

Feature Type

protein coding gene

Genetic Map

Chromosome 2

19.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:27188393-27248337 bp, - strand From VEGA annotation of GRCm38   59945 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5149  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sardh

Human homologs

Human Homolog		SARDH, sarcosine dehydrogenase
NCBI Gene ID		1757
neXtProt AC		NX_Q9UL12
Human Synonyms		BPR-2, DMGDHL1, SAR, SARD, SDH
Human Chr (Location)		9q33-q34; chr9:136528682-136605077 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SARDH

Alleles and phenotypes

All alleles(3) : Targeted(3)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	glycine catabolic process, oxidation-reduction process
Component	cytoplasm, mitochondrial matrix, ...
Function	aminomethyltransferase activity, flavin adenine dinucleotide binding, ...

External Resources: FuncBase

Expression

cDNA source data(152)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(153) cDNA(152) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000012037 (Evidence)
Ensembl Gene Model	ENSMUSG00000009614 (Evidence)
Entrez Gene	192166 (Evidence)
UniGene	278467
DFCI	TC1575190, TC1579917, TC1694843
DoTS	DT.110654709, DT.493914, DT.55129459
NIA Mouse Gene Index	U022441
EC	1.5.8.3
Consensus CDS Project	CCDS15826.1
International Mouse Knockout Project Status	Sardh

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012037	VEGA Gene Model | MGI Sequence Detail	59945	C57BL/6J
transcript	OTTMUST00000028625	VEGA | MGI Sequence Detail	4521	Not Applicable
polypeptide	OTTMUSP00000012947	VEGA | MGI Sequence Detail	919	Not Applicable

All sequences(71) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(450 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006076	FAD dependent oxidoreductase
InterPro	IPR013977	Glycine cleavage T-protein, C-terminal barrel
InterPro	IPR006222	Glycine cleavage T-protein, N-terminal
Protein Ontology	PR:000014456	sarcosine dehydrogenase, mitochondrial

References

(Earliest) J:86816 Mootha VK, et al., Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell. 2003 Nov 26;115(5):629-40
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)