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Sardh Gene Detail
Summary
  • Symbol
    Sardh
  • Name
    sarcosine dehydrogenase
  • Synonyms
    MGC:6279
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183102
    NCBI Gene: 192166
  • Gene Overview
    MyGene.info: SARDH
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:27188393-27248332 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 19.31 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    468 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183102
protein coding gene Chr2:27188393-27248337 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025512
protein coding gene Chr2:25164136-25225442 (-)
A/J MGP_AJ_G0025489
protein coding gene Chr2:24214300-24274936 (-)
AKR/J MGP_AKRJ_G0025459
protein coding gene Chr2:25008804-25068670 (-)
BALB/cJ MGP_BALBcJ_G0025485
protein coding gene Chr2:24332591-24393803 (-)
C3H/HeJ MGP_C3HHeJ_G0025246
protein coding gene Chr2:24942830-25005118 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025929
protein coding gene Chr2:26014924-26076894 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023340
protein coding gene Chr2:23047448-23106288 (-)
CAST/EiJ MGP_CASTEiJ_G0024709
protein coding gene Chr2:24823393-24884044 (-)
CBA/J MGP_CBAJ_G0025224
protein coding gene Chr2:26920404-26983472 (-)
DBA/2J MGP_DBA2J_G0025357
protein coding gene Chr2:24035770-24095994 (-)
FVB/NJ MGP_FVBNJ_G0025319
protein coding gene Chr2:23792843-23854892 (-)
LP/J MGP_LPJ_G0025443
protein coding gene Chr2:25105265-25170795 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025350
protein coding gene Chr2:26957603-27022244 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025988
protein coding gene Chr2:24942519-25002321 (-)
PWK/PhJ MGP_PWKPhJ_G0024457
protein coding gene Chr2:23826467-23887233 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024257
protein coding gene Chr2:25086140-25150704 (-)
WSB/EiJ MGP_WSBEiJ_G0024778
protein coding gene Chr2:25058873-25119553 (-)



Homology
more
  • Human Ortholog
    SARDH, sarcosine dehydrogenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SARDH, sarcosine dehydrogenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BPR-2, DMGDHL1, SAR, SARD, SDH
  • Links
    NCBI Gene ID: 1757
    neXtProt AC: NX_Q9UL12
    UniProt: Q9UL12

  • Chr Location
    9q34.2; chr9:133663074-133739958 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5149
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SARDH
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 192166 NCBI Gene Model | MGI Sequence Detail 59940 C57BL/6J ±  kb
transcript NM_138665 RefSeq | MGI Sequence Detail 4573 C57BL/6  
polypeptide Q99LB7 UniProt | EBI | MGI Sequence Detail 919 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000014456 sarcosine dehydrogenase, mitochondrial
  • EC
  • InterPro Domains
    IPR006222 Aminomethyltransferase, folate-binding domain
    IPR006076 FAD dependent oxidoreductase
    IPR032503 FAD dependent oxidoreductase, central domain
    IPR036188 FAD/NAD(P)-binding domain superfamily
    IPR013977 Glycine cleavage T-protein, C-terminal barrel domain
    IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal
    IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1
Molecular
Reagents
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  • All nucleic 154
    cDNA 153
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 27
    Gene Ontology 7
    Phenotypes 3
  • Earliest
    J:86816 Mootha VK, et al., Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell. 2003 Nov 26;115(5):629-40
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory