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Tifa Gene Detail
Summary
  • Symbol
    Tifa
  • Name
    TRAF-interacting protein with forkhead-associated domain
  • Synonyms
    T2bp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182965
    NCBI Gene: 211550
  • Alliance
    genome feature page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:127582524-127592043 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 56.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    365 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182965
 protein coding gene Chr3:127582524-127625813 (+)
129S1/SvImJ ENSMUSG00200002741
 protein coding gene Chr3:124318590-124327176 (+)
A/J ENSMUSG00195007902
 protein coding gene Chr3:124457343-124465940 (+)
AKR/J ENSMUSG00220021882
 protein coding gene Chr3:122898130-122906717 (+)
BALB/cJ ENSMUSG00180003462
 protein coding gene Chr3:124384466-124393060 (+)
C3H/HeJ ENSMUSG00175012438
 protein coding gene Chr3:123938154-123946738 (+)
C57BL/6NJ ENSMUSG00215017305
 protein coding gene Chr3:124729000-124737586 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025618
 protein coding gene Chr3:121079034-121121453 (+)
CAST/EiJ ENSTCUG00005003592
 protein coding gene Chr3:125027130-125035768 (+)
CBA/J ENSMUSG00210003383
 protein coding gene Chr3:124561350-124569940 (+)
DBA/2J ENSMUSG00185025534
 protein coding gene Chr3:125181905-125190488 (+)
FVB/NJ ENSMUSG00205022084
 protein coding gene Chr3:123527454-123536037 (+)
JF1/MsJ ENSUMUG00000026340
 protein coding gene Chr3:123929938-123938559 (+)
LP/J ENSMUSG00230002703
 protein coding gene Chr3:127150800-127160475 (+)
NOD/ShiLtJ ENSMUSG00190001445
 protein coding gene Chr3:125584339-125592976 (+)
NZO/HlLtJ ENSMUSG00225002225
 protein coding gene Chr3:129616566-129625149 (+)
PWK/PhJ ENSLUMG00010015206
 protein coding gene Chr3:123951067-123959719 (+)
SPRET/EiJ ENSMSPG00010012212
 protein coding gene Chr3:124870054-124878667 (+)
WSB/EiJ ENSIUOG00005015876
 protein coding gene Chr3:124746151-124754771 (+)



Homology
more
  • Human Ortholog
    TIFA, TRAF interacting protein with forkhead associated domain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIFA, TRAF interacting protein with forkhead associated domain
  • Synonyms
    T2BP, T6BP, TIFAA
  • Links
    NCBI Gene ID: 92610
    UniProt: Q96CG3

  • Chr Location
    4q25; chr4:112272968-112285955 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    676
  • Tissues
    10
  • cDNA Data
    29
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 211550 NCBI Gene Model | MGI Sequence Detail 9520 C57BL/6J ±  kb
transcript NM_145133 RefSeq | MGI Sequence Detail 2183 C57BL/6  
polypeptide Q793I8 UniProt | EBI | MGI Sequence Detail 184 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    cDNA 29

    Microarray probesets 3
References
more
  • Summaries
    All 53
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:372687 Agarwal P, et al., Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1. Nature. 2025 Jun;642(8066):201-211
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory