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Rxfp4 Gene Detail
Summary
  • Symbol
    Rxfp4
  • Name
    relaxin family peptide receptor 4
  • Synonyms
    Gpr100, Rln3r2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182926
    NCBI Gene: 242093
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr3:88651898-88653142 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    50 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182926
protein coding gene Chr3:88651898-88653142 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027405
protein coding gene Chr3:88831079-88832323 (-)
A/J MGP_AJ_G0027369
protein coding gene Chr3:85830710-85831954 (-)
AKR/J MGP_AKRJ_G0027333
protein coding gene Chr3:87948525-87949769 (-)
BALB/cJ MGP_BALBcJ_G0027378
protein coding gene Chr3:85915337-85916581 (-)
C3H/HeJ MGP_C3HHeJ_G0027120
protein coding gene Chr3:88207243-88208487 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027824
protein coding gene Chr3:92133102-92134346 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025176
protein coding gene Chr3:81436229-81437631 (-)
CAST/EiJ MGP_CASTEiJ_G0026566
protein coding gene Chr3:88443969-88445213 (-)
CBA/J MGP_CBAJ_G0027094
protein coding gene Chr3:95299378-95300622 (-)
DBA/2J MGP_DBA2J_G0027232
protein coding gene Chr3:85313126-85314370 (-)
FVB/NJ MGP_FVBNJ_G0027200
protein coding gene Chr3:83583863-83585107 (-)
LP/J MGP_LPJ_G0027341
protein coding gene Chr3:89843781-89845025 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027220
protein coding gene Chr3:101506067-101507311 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027883
protein coding gene Chr3:87695183-87696427 (-)
PWK/PhJ MGP_PWKPhJ_G0026300
protein coding gene Chr3:85096298-85097543 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026119
protein coding gene Chr3:86881079-86882323 (-)
WSB/EiJ MGP_WSBEiJ_G0026648
protein coding gene Chr3:88050440-88051684 (-)



Homology
more
  • Human Ortholog
    RXFP4, relaxin family peptide/INSL5 receptor 4
  • Vertebrate Orthologs
    6
  • Human Ortholog
    RXFP4, relaxin family peptide/INSL5 receptor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPCR142, GPR100, RLN3R2, RXFPR4
  • Links
    NCBI Gene ID: 339403
    neXtProt AC: NX_Q8TDU9
    UniProt: Q8TDU9

  • Chr Location
    1q22; chr1:155941689-155942834 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced refeeding responses after fasting, altered food preference, and reduced fat content.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 242093 NCBI Gene Model | MGI Sequence Detail 1245 C57BL/6J ±  kb
transcript NM_181817 RefSeq | MGI Sequence Detail 1245 Not Specified  
polypeptide Q7TQP4 UniProt | EBI | MGI Sequence Detail 414 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 1
References
more
  • Summaries
    All 28
    Diseases 1
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:212239 Grosse J, et al., Insulin-like peptide 5 is an orexigenic gastrointestinal hormone. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11133-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory