Serpina3h Pseudogene Detail

Summary

• Symbol
  Serpina3h
• Name
  serine (or cysteine) peptidase inhibitor, clade A, member 3H
• Synonyms
  6C28, alpha-1 antiproteinase

• Feature Type
  pseudogene
  BioType Conflict
  
• IDs
  MGI:2182839
  NCBI Gene: 546546
• Alliance
  genome feature page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr12:104214155-104220664 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, 53.74 cM, cytoband F1
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  469 from dbSNP Build 142
• Strain Annotations
  24

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2182839	pseudogene	Chr12:104214042-104220679 (+)
129S1/SvImJ	ENSMUSG00200029548	pseudogene	Chr12:95945745-95952295 (+)
A/J	ENSMUSG00195021571	pseudogene	Chr12:98541709-98548259 (+)
AKR/J	ENSMUSG00220044585	pseudogene	Chr12:96351026-96357574 (+)
AKR/J	ENSMUSGG00220054907	protein coding gene	Chr12:96353305-96357564 (+)
BALB/cJ	ENSMUSG00180039561	pseudogene	Chr12:97684707-97691255 (+)
BALB/cJ	ENSMUSGG00180055321	protein coding gene	Chr12:97686986-97691245 (+)
C3H/HeJ	ENSMUSG00175035283	pseudogene	Chr12:100353892-100360442 (+)
C57BL/6NJ	ENSMUSG00215041496	pseudogene	Chr12:97015808-97022358 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	ENSTCUG00005021399	pseudogene	Chr12:96456196-96462747 (+)
CBA/J	ENSMUSGG00210054808	protein coding gene	Chr12:97378940-97383199 (+)
CBA/J	ENSMUSG00210015227	pseudogene	Chr12:97376661-97383209 (+)
DBA/2J	ENSMUSGG00185057888	protein coding gene	Chr12:99145030-99149289 (+)
DBA/2J	ENSMUSG00185047478	pseudogene	Chr12:99142751-99149299 (+)
FVB/NJ	ENSMUSG00205022989	pseudogene	Chr12:96379078-96383349 (+)
FVB/NJ	ENSMUSG00205020457	pseudogene	Chr12:96361341-96367905 (+)
JF1/MsJ	ENSUMUG00000041643	pseudogene	Chr12:103909133-103915683 (+)
LP/J	ENSMUSG00230032762	pseudogene	Chr12:106210723-106217273 (+)
NOD/ShiLtJ	ENSMUSG00190035089	pseudogene	Chr12:88829686-88836234 (-)
NOD/ShiLtJ	ENSMUSG00190021860	protein coding gene	Chr12:88829696-88836245 (-)
NZO/HlLtJ	ENSMUSG00225038711	pseudogene	Chr12:107980447-107986997 (+)
PWK/PhJ	ENSLUMG00010014318	pseudogene	Chr12:97351668-97358219 (+)
SPRET/EiJ	ENSMSPG00010020810	pseudogene	Chr12:99714868-99720233 (+)
WSB/EiJ	ENSIUOG00005009889	pseudogene	Chr12:96387550-96394109 (+)

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  1
• Chemically induced (other)
  1
• Genomic Mutations
  1 involving Serpina3h
• Find Mice (IMSR)
  0 strains or lines available

Expression

• cDNA Data
  6

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  55
• RefSeq
  1
• UniProt
  2
• CCDS
  CCDS36535.1

• Ensembl
  ENSMUSG00000041449 (Evidence), ENSMUSG00000121484 (Evidence)
• NCBI Gene
  546546

Representative Sequences			Length	Strain/Species
genomic	546546	NCBI Gene Model | MGI Sequence Detail	6510	C57BL/6J
transcript	NR_033450	RefSeq | MGI Sequence Detail	2051	C57BL/6
polypeptide	A2RTV1	UniProt | EBI | MGI Sequence Detail	409	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• InterPro Domains
  IPR023795 Serpin, conserved site
  IPR023796 Serpin domain
  IPR000215 Serpin family
  IPR036186 Serpin superfamily
  IPR042178 Serpin superfamily, domain 1
  IPR042185 Serpin superfamily, domain 2

Molecular
Reagents

• All nucleic 6

  cDNA 6

References

• Summaries
  All 15

  Phenotypes 2
• Earliest
  J:25107 Inglis JD, et al., The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain. EMBO J. 1991 Feb;10(2):255-61
• Latest
  J:97996 Winkler IG, et al., Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. J Exp Med. 2005 Apr 4;201(7):1077-88

TSS for Serpina3h:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114838	Chr12:104214151-104214156 (+)	-1 bp