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Lgi3 Gene Detail
Summary
  • Symbol
    Lgi3
  • Name
    leucine-rich repeat LGI family, member 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182619
    NCBI Gene: 213469
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70530685-70538324 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182619
protein coding gene Chr14:70528547-70538324 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021541
protein coding gene Chr14:65184496-65194066 (+)
A/J MGP_AJ_G0021500
protein coding gene Chr14:63800143-63808218 (+)
AKR/J MGP_AKRJ_G0021476
protein coding gene Chr14:65712082-65719471 (+)
BALB/cJ MGP_BALBcJ_G0021506
protein coding gene Chr14:63563108-63570612 (+)
C3H/HeJ MGP_C3HHeJ_G0021283
protein coding gene Chr14:65426753-65435510 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021945
protein coding gene Chr14:68097928-68105430 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019485
protein coding gene Chr14:61637575-61644936 (+)
CAST/EiJ MGP_CASTEiJ_G0020800
protein coding gene Chr14:62021146-62030061 (+)
CBA/J MGP_CBAJ_G0021250
protein coding gene Chr14:70237753-70245474 (+)
DBA/2J MGP_DBA2J_G0021373
protein coding gene Chr14:63183909-63191493 (+)
FVB/NJ MGP_FVBNJ_G0021352
protein coding gene Chr14:62613960-62621840 (+)
LP/J MGP_LPJ_G0021444
protein coding gene Chr14:66428426-66435957 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021381
protein coding gene Chr14:69125934-69133609 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021969
protein coding gene Chr14:64975009-64982511 (+)
PWK/PhJ MGP_PWKPhJ_G0020544
protein coding gene Chr14:59951312-59959042 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020377
protein coding gene Chr14:60902479-60909956 (+)
WSB/EiJ MGP_WSBEiJ_G0020853
protein coding gene Chr14:65287130-65296174 (+)



Homology
more
  • Human Ortholog
    LGI3, leucine rich repeat LGI family member 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LGI3, leucine rich repeat LGI family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LGIL4
  • Links
    NCBI Gene ID: 203190
    neXtProt AC: NX_Q8N145
    UniProt: Q8N145

  • Chr Location
    8p21.3; chr8:22146830-22156831 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033595 Ensembl Gene Model | MGI Sequence Detail 7640 C57BL/6J ±  kb
    transcript ENSMUST00000047331 Ensembl | MGI Sequence Detail 3174 Not Applicable  
    polypeptide ENSMUSP00000046705 Ensembl | MGI Sequence Detail 548 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2145695, MGI:2145791
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:77120 Gu W, et al., The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins. FEBS Lett. 2002 May 22;519(1-3):71-6
    • Latest
      J:260471 Gerhardt B, et al., Notum attenuates Wnt/beta-catenin signaling to promote tracheal cartilage patterning. Dev Biol. 2018 Apr 1;436(1):14-27

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/10/2020
    MGI 6.16
    The Jackson Laboratory