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Lgi3 Gene Detail
Summary
  • Symbol
    Lgi3
  • Name
    leucine-rich repeat LGI family, member 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182619
    NCBI Gene: 213469
Location & Maps
more
  • Sequence Map
    Chr14:70530821-70538323 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7503 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LGI3, leucine rich repeat LGI family member 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LGI3, leucine rich repeat LGI family member 3
    Orthology source: HomoloGene
  • Synonyms
    LGIL4
  • Links
    NCBI Gene ID: 203190
    neXtProt AC: NX_Q8N145

  • Chr Location
    8p21.3; chr8:22146830-22156831 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Lgi3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033595 Ensembl Gene Model | MGI Sequence Detail 7503 C57BL/6J ±  kb
transcript ENSMUST00000047331 Ensembl | MGI Sequence Detail 3180 Not Applicable  
polypeptide ENSMUSP00000046705 Ensembl | MGI Sequence Detail 548 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    62 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000031155 leucine-rich repeat LGI family member 3
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR005492 Leucine-rich glioma-inactivated , EPTP repeat
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003591 Leucine-rich repeat, typical subtype
    IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase
Molecular
Reagents
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  • All nucleic 13
    cDNA 13

    Microarray probesets 2
Other
Accession IDs
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MGI:2145695, MGI:2145791
References
more
  • Summaries
    All 27
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:77120 Gu W, et al., The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins. FEBS Lett. 2002 May 22;519(1-3):71-6
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory