Lgi3 MGI Mouse Gene Detail - MGI:2182619 - leucine-rich repeat LGI family, member 3

Symbol

Lgi3
Name

leucine-rich repeat LGI family, member 3

Feature Type

protein coding gene
IDs

MGI:2182619
NCBI Gene: 213469
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr14:70768125-70775764 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 36.32 cM
Mapping Data

2 experiments

SNPs within 2kb

62 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2182619	protein coding gene	Chr14:70765987-70775764 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021541	protein coding gene	Chr14:65184496-65194066 (+)
A/J	MGP_AJ_G0021500	protein coding gene	Chr14:63800143-63808218 (+)
AKR/J	MGP_AKRJ_G0021476	protein coding gene	Chr14:65712082-65719471 (+)
BALB/cJ	MGP_BALBcJ_G0021506	protein coding gene	Chr14:63563108-63570612 (+)
C3H/HeJ	MGP_C3HHeJ_G0021283	protein coding gene	Chr14:65426753-65435510 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021945	protein coding gene	Chr14:68097928-68105430 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019485	protein coding gene	Chr14:61637575-61644936 (+)
CAST/EiJ	MGP_CASTEiJ_G0020800	protein coding gene	Chr14:62021146-62030061 (+)
CBA/J	MGP_CBAJ_G0021250	protein coding gene	Chr14:70237753-70245474 (+)
DBA/2J	MGP_DBA2J_G0021373	protein coding gene	Chr14:63183909-63191493 (+)
FVB/NJ	MGP_FVBNJ_G0021352	protein coding gene	Chr14:62613960-62621840 (+)
LP/J	MGP_LPJ_G0021444	protein coding gene	Chr14:66428426-66435957 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021381	protein coding gene	Chr14:69125934-69133609 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021969	protein coding gene	Chr14:64975009-64982511 (+)
PWK/PhJ	MGP_PWKPhJ_G0020544	protein coding gene	Chr14:59951312-59959042 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020377	protein coding gene	Chr14:60902479-60909956 (+)
WSB/EiJ	MGP_WSBEiJ_G0020853	protein coding gene	Chr14:65287130-65296174 (+)

Human Ortholog

LGI3, leucine rich repeat LGI family member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LGI3, leucine rich repeat LGI family member 3
Synonyms

IDDMDS, LGIL4
Links

HGNC:18711

NCBI Gene ID: 203190

neXtProt AC: NX_Q8N145

UniProt: Q8N145
Chr Location

8p21.3; chr8:22146830-22157084 (-) GRCh38

MGI Vertebrate Homology

Lgi3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LGI3
Gene Tree

Lgi3

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Phenotype Summary

11 phenotypes from 2 alleles in 3 genetic backgrounds
4 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

4
Genomic Mutations

1 involving Lgi3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele have reduced and mis-localized Kv1 channel complexes in myelinated peripheral axons. A null IMPC allele shows enlarged kidney and spleen and thick skin.

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All GO Annotations

10
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

916
Tissues

75
cDNA Data

13
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

45
RefSeq

5
UniProt

3
CCDS

CCDS27255.1

Ensembl

ENSMUSG00000033595 (Evidence)
NCBI Gene

213469

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033595	Ensembl Gene Model \| MGI Sequence Detail	7640	C57BL/6J	± kb
transcript	ENSMUST00000047331	Ensembl \| MGI Sequence Detail	3174	Not Applicable
polypeptide	ENSMUSP00000046705	Ensembl \| MGI Sequence Detail	548	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031155 leucine-rich repeat LGI family member 3

(term hierarchy)
InterPro Domains

IPR000483 Cysteine-rich flanking region, C-terminal

IPR009039 EAR

IPR005492 Leucine-rich glioma-inactivated , EPTP repeat

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase

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All nucleic 17

cDNA 14

Primer pair 1

Other 2

Microarray probesets 2

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MGI:2145695, MGI:2145791

Summaries

All 46

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 13
Earliest

J:77120 Gu W, et al., The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins. FEBS Lett. 2002 May 22;519(1-3):71-6
Latest

J:345940 Miyazaki Y, et al., Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity. Cell Rep. 2024 Jan 23;43(1):113634

TSS for Lgi3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126439	Chr14:70768000-70768011 (+)	-119 bp
Tssr126440	Chr14:70768021-70768039 (+)	-95 bp
Tssr126441	Chr14:70768051-70768064 (+)	-67 bp
Tssr126442	Chr14:70768100-70768131 (+)	-9 bp
Tssr126443	Chr14:70768259-70768287 (+)	148 bp
Tssr126444	Chr14:70768289-70768319 (+)	179 bp
Tssr126445	Chr14:70768339-70768350 (+)	220 bp
Tssr126446	Chr14:70768436-70768443 (+)	315 bp
Tssr126447	Chr14:70769060-70769070 (+)	940 bp
Tssr126448	Chr14:70769092-70769113 (+)	978 bp
Tssr126449	Chr14:70769117-70769133 (+)	1,000 bp
Tssr126450	Chr14:70769141-70769152 (+)	1,022 bp
Tssr126451	Chr14:70771849-70771861 (+)	3,730 bp
Tssr126452	Chr14:70773644-70773668 (+)	5,531 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23