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Grhl1
Gene Detail
Symbol

Name
ID
Grhl1
grainyhead-like 1 (Drosophila)
MGI:2182540
Synonyms
LBP-32, p61 MGR, p70 MGR, Tcfcp2l2
Feature Type
protein coding gene
Genetic Map
Chromosome 12
8.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:24572287-24617391 bp, + strand
From Ensembl annotation of GRCm38

  45105 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32219  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Grhl1

Human
homologs
Human Homolog GRHL1, grainyhead-like 1 (Drosophila)
NCBI Gene ID 29841
neXtProt AC  NX_Q9NZI5
Human Synonyms  LBP32, MGR, NH32, TFCP2L2
Human Chr (Location)  2p25.1; chr2:9951663-10002284 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display alopecia or sparse hair, abnormal hair follicle root sheaths, thickening of the cornified layer on the paws, and postnatal growth retardation.
 
Human Diseases Modeled Using Mouse Grhl1 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Interactions
Grhl1 interacts with 260 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (11 records)
Data Summary: Results (309)    Tissues (194)    Images (72)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 301
RT-PCR 8
cDNA source data(61)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(62) cDNA(61) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000020656 (Evidence)
Entrez Gene195733 (Evidence)
UniGene263068
DFCITC1578876, TC1723826
DoTSDT.91373039, DT.94376176, DT.40151278, DT.40158298, DT.101365062
NIA Mouse Gene IndexU013801
Consensus CDS ProjectCCDS36420.1, CCDS49038.1
International Mouse Knockout Project StatusGrhl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020656 Ensembl Gene Model | MGI Sequence Detail 45105 C57BL/6J ±  kb
transcript ENSMUST00000085553 Ensembl | MGI Sequence Detail 3464 Not Applicable 
polypeptide ENSMUSP00000082689 Ensembl | MGI Sequence Detail 618 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(446 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007604 CP2 transcription factor
Protein Ontology PR:000008229 grainyhead-like protein 1
References
(Earliest) J:76635 Wilanowski T, et al., A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech Dev. 2002 Jun;114(1-2):37-50
(Latest) J:213760 Mlacki M, et al., Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin. PLoS One. 2014;9(2):e89247
All references(42)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory