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Grhl1
Gene Detail
 Symbol
Name
ID
Grhl1
grainyhead-like 1 (Drosophila)
MGI:2182540
Synonyms LBP-32, p61 MGR, p70 MGR, Tcfcp2l2
Feature Type protein coding gene
Genetic Map
Chromosome 12
8.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:24572287-24617391 bp, + strand
From NCBI annotation of GRCm38

  45105 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32219  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Grhl1

Human
homologs
Human Homolog GRHL1, grainyhead-like 1 (Drosophila)
NCBI Gene ID 29841
neXtProt AC  NX_Q9NZI5
Human Synonyms  LBP32, MGR, NH32, TFCP2L2
Human Chr (Location)  2p25.1; chr2:9951663-10002284 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display alopecia or sparse hair, abnormal hair follicle root sheaths, thickening of the cornified layer on the paws, and postnatal growth retardation.
 
Human Diseases Modeled Using Mouse Grhl1 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Interactions
Grhl1 interacts with 260 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process multicellular organismal development, regulation of transcription, DNA-templated, ...
Component cytoplasm, Golgi apparatus, ...
Function DNA binding, sequence-specific DNA binding transcription factor activity
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (309)    Tissues (194)    Images (72)
Theiler Stages: 2, 3, 4, 5, 13, 17, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 301
RT-PCR 8
cDNA source data(61)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(62) cDNA(61) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000020656 (Evidence)
Entrez Gene195733 (Evidence)
UniGene263068
DFCITC1578876, TC1723826
DoTSDT.101365062, DT.40151278, DT.40158298, DT.91373039, DT.94376176
NIA Mouse Gene IndexU013801
Consensus CDS ProjectCCDS36420.1, CCDS49038.1
International Mouse Knockout Project StatusGrhl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 195733 NCBI Gene Model | MGI Sequence Detail 45105 C57BL/6J ±  kb
transcript NM_001161406 RefSeq | MGI Sequence Detail 3487 C57BL/6 
polypeptide Q921D9 UniProt | EBI | MGI Sequence Detail 618 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(446 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007604 CP2 transcription factor
Protein Ontology PR:000008229 grainyhead-like protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:76635 Wilanowski T, et al., A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech Dev. 2002 Jun;114(1-2):37-50
(Latest) J:168020 Boglev Y, et al., The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity. Dev Biol. 2011 Jan 15;349(2):512-22
All references(40)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory