About   Help   FAQ
Sgk3 Gene Detail
Summary
  • Symbol
    Sgk3
  • Name
    serum/glucocorticoid regulated kinase 3
  • Synonyms
    2510015P22Rik, A330005P07Rik, Cisk, cytokine-independent survival kinase, fy, Sgkl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182368
    NCBI Gene: 170755
Location & Maps
more
  • Sequence Map
    Chr1:9798107-9900845 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      102739 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 2.08 cM
  • Mapping Data
    53 experiments
Homology
more
  • Human Ortholog
    C8orf44-SGK3, C8orf44-SGK3 readthrough
  • Vertebrate Orthologs
    11
  • Human Ortholog
    C8orf44-SGK3, C8orf44-SGK3 readthrough
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 100533105
    neXtProt AC: NX_Q96BR1

  • Chr Location
    chr8:66667552-66862022 (+)  GRCh38.p2

  • Human Ortholog
    SGK3, serum/glucocorticoid regulated kinase family member 3
    Orthology source: HomoloGene
  • Synonyms
    CISK, SGK2, SGKL
  • Links
    NCBI Gene ID: 23678
    neXtProt AC: NX_Q96BR1

  • Chr Location
    8q12; chr8:66712418-66862022 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 10 alleles in 10 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (ENU)
    1
  • Gene trapped
    7
  • Spontaneous
    7
  • Targeted
    2
  • Incidental Mutations
Mutations in this gene result in wavy vibrissae and coat/ hair abnormalities, including sparse and waved hair, due to impaired hair follicle development and/or hair cycle defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045250 VEGA Gene Model | MGI Sequence Detail 102739 C57BL/6J ±  kb
transcript OTTMUST00000118855 VEGA | MGI Sequence Detail 3706 Not Applicable  
polypeptide OTTMUSP00000066283 VEGA | MGI Sequence Detail 496 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    625 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 68
    cDNA 67
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-9908, MGD-MRK-9910, MGI:1919672, MGI:2443375, MGI:95603
References
more
  • Summaries
    All 79
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 30
  • Earliest
    J:90 DICKIE MM, et al., Fuzzy mice. J Hered. 1950 Jul;41(7):193-6
  • Latest
    J:219500 Gasser JA, et al., SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Mol Cell. 2014 Nov 20;56(4):595-607

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory